Beyond the ABCs of CKC and SCC: Do centromeres orchestrate sister chromatid cohesion or vice versa? Journal Article
| Authors: | Meluh, P. B.; Strunnikov, A. V. |
| Article Title: | Beyond the ABCs of CKC and SCC: Do centromeres orchestrate sister chromatid cohesion or vice versa? |
| Abstract: | The centromere-kinetochore complex is a highly specialized chromatin domain that both mediates and monitors chromosome-spindle interactions responsible for accurate partitioning of sister chromatids to daughter cells. Centromeres are distinguished from adjacent chromatin by specific patterns of histone modification and the presence of a centromere-specific histone H3 variant (e.g. CENP-A). Centromere-proximal regions usually correspond to sites of avid and persistent sister chromatid cohesion mediated by the conserved cohesin complex. In budding yeast, there is a substantial body of evidence indicating centromeres direct formation and/or stabilization of centromere-proximal cohesion. In other organisms, the dependency of cohesion on centromere function is not as clear. Indeed, it appears that pericentromeric heterochromatin recruits cohesion proteins independent of centromere function. Nonetheless, aspects of centromere function are impaired in the absence of sister chromatid cohesion, suggesting the two are interdependent. Here we review the nature of centromeric chromatin, the dynamics and regulation of sister chromatid cohesion, and the relationship between the two. |
| Keywords: | protein expression; protein phosphorylation; unclassified drug; methylation; nonhuman; dna polymerase; cohesin; chromosome structure; meiosis; animals; chromosomal proteins, non-histone; sister chromatid; unindexed drug; protein degradation; protein; protein interaction; enzyme activity; dna; histone; chromatin; chromatin immunoprecipitation; histone h3; short survey; dna sequence; saccharomycetales; sequence homology; dna binding; adenosine triphosphatase; histone h2a; histone h2b; centromere; heterochromatin; chromatids; histone h4; heterochromatin protein 1; protein mad2; kinetochores; sister chromatid cohesion; protein scc2; protein scc4; kinetochore; cenp-a; protein eco1; protein pds5; protein scc3; humans; human; priority journal; protein eso1; centromere protein a; protein bir1; protein cenp h; protein ctf7; protein incenp; protein ip11; protein psc3; protein rad21; protein sli15; protein smc1; protein smc2; protein smc4 |
| Journal Title: | European Journal of Biochemistry |
| Volume: | 269 |
| Issue: | 9 |
| ISSN: | 0014-2956 |
| Publisher: | Blackwell Publishing |
| Date Published: | 2002-05-01 |
| Start Page: | 2300 |
| End Page: | 2314 |
| Language: | English |
| DOI: | 10.1046/j.1432-1033.2002.02886.x |
| PUBMED: | 11985612 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
