A coactivator code for transcription Journal Article
| Authors: | Gamble, M. J.; Freedman, L. P. |
| Article Title: | A coactivator code for transcription |
| Abstract: | The study of the covalent modifications of the N-terminal tails of histones and their effects on chromatin structure and function, known as 'the histone code', is proceeding at a rapid pace. Recent work by several groups suggests that coactivators, such as p300/CBP, are also controlled by an array of various covalent modifications. This suggests the existence of a 'coactivator code' for p300/CBP and other seemingly promiscuous coregulators. Such a code could have wide-reaching implications for conferring specificity to general, ubiquitous transcriptional regulatory factors. |
| Keywords: | protein conformation; transcription initiation; transcription factor; gene function; transcription, genetic; transcription regulation; amino terminal sequence; histone; chromatin; gene repression; transactivation; short survey; trans-activators; histones; protein methylation; chromatin structure; cyclic amp responsive element binding protein; chemical modification; protein p300; priority journal |
| Journal Title: | Trends in Biochemical Sciences |
| Volume: | 27 |
| Issue: | 4 |
| ISSN: | 0968-0004 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-04-01 |
| Start Page: | 165 |
| End Page: | 167 |
| Language: | English |
| DOI: | 10.1016/s0968-0004(02)02076-5 |
| PUBMED: | 11943535 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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