A Smad transcriptional corepressor Journal Article
| Authors: | Wotton, D.; Lo, R. S.; Lee, S.; Massagué, J. |
| Article Title: | A Smad transcriptional corepressor |
| Abstract: | Following TGFβ receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein and a repressor of transcription. A TGFβ-activated Smad complex can recruit TGIF and histone deacetylases (HDACs) to a Smad target promoter, repressing transcription. Thus, upon entering the nucleus, a Smad2-Smad4 complex may interact with coactivators, forming a transcriptional activation complex, or with TGIF and HDACs, forming a transcriptional repressor complex. Formation of one of these two mutually exclusive complexes is determined by the relative levels of Smad corepressors and coactivators within the cell. |
| Keywords: | signal transduction; protein phosphorylation; dna binding protein; promoter region; nonhuman; protein analysis; protein protein interaction; regulatory mechanism; transcription regulation; nucleotide sequence; transforming growth factor beta receptor; homeodomain protein; dna binding; histone deacetylase; acetylation; priority journal; article |
| Journal Title: | Cell |
| Volume: | 97 |
| Issue: | 1 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 1999-04-02 |
| Start Page: | 29 |
| End Page: | 39 |
| Language: | English |
| PUBMED: | 10199400 |
| PROVIDER: | scopus |
| DOI: | 10.1016/S0092-8674(00)80712-6 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 16 August 2016 -- Source: Scopus |
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