Copper-64 Radiopharmaceuticals for Oncologic Imaging Journal Article
| Authors: | Holland, J. P.; Ferdani, R.; Anderson, C. J.; Lewis, J. S. |
| Article Title: | Copper-64 Radiopharmaceuticals for Oncologic Imaging |
| Abstract: | The positron emitting radionuclide <sup>64</sup>Cu has a radioactive half-life of 12.7 hours. The decay characteristics of <sup>64</sup>Cu allow for PET images that are comparable in quality to those obtained using <sup>18</sup>F. Given the longer radioactive half-life of <sup>64</sup>Cu compared with <sup>18</sup>F and the versatility of copper chemistry, copper is an attractive alternative to the shorter-lived nuclides for PET imaging of peptides, antibodies, and small molecules that may require longer circulation times. This article discusses a number of copper radiopharmaceuticals, such as Cu-ATSM, that have been translated to the clinic and new developments in copper-based radiopharmaceuticals. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | epidermal growth factor; cancer survival; treatment outcome; unclassified drug; review; fluorouracil; nonhuman; drug targeting; cancer radiotherapy; positron emission tomography; radiopharmaceuticals; colorectal cancer; unindexed drug; tumor volume; epidermal growth factor receptor; small interfering rna; continuous infusion; drug structure; cetuximab; prediction; monoclonal antibody; colorectal carcinoma; neuroendocrine tumor; pathological anatomy; drug distribution; diagnostic value; image quality; colon cancer; fluorodeoxyglucose f 18; computer assisted emission tomography; peptides; radiopharmaceutical agent; malignant neoplastic disease; nanoparticle; octreotide; antibodies; polystyrene; drug half life; fluorine 18; rectum carcinoma; single photon emission computer tomography; pet; integrin; copper 64; 1,4,7,10 tetraazacyclododecane 1,4,7,10 tetraacetic acid; angiopeptin; arginylglycylaspartic acid; copper 62; diacetyl 2,3 bis(n4 methylthiosemicarbazone); fluorescein isothiocyanate; gallium 68; macrogol; methylglyoxal bis(4 n methylthiosemicarbazone); monocrystalline iron oxide nanoparticle; nickel; octreotide[3 tyrosine]; quantum dot; thiosemicarbazone derivative; zirconium; alzheimer disease; radioisotope decay |
| Journal Title: | PET Clinics |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 1556-8598 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2009-01-01 |
| Start Page: | 49 |
| End Page: | 67 |
| Language: | English |
| DOI: | 10.1016/j.cpet.2009.04.013 |
| PROVIDER: | scopus |
| PMCID: | PMC4961094 |
| PUBMED: | 27156895 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 30 November 2010" - "Source: Scopus" |
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