A genome-wide association study of marginal zone lymphoma shows association to the HLA region Journal Article
| Authors: | Vijai, J.; Wang, Z. M.; Berndt, S. I.; Skibola, C. F.; Slager, S. L.; De Sanjose, S.; Melbye, M.; Glimelius, B.; Bracci, P. M.; Conde, L.; Birmann, B. M.; Wang, S. S.; Brooks-Wilson, A. R.; Lan, Q.; de Bakker, P. I. W.; Vermeulen, R. C. H.; Portlock, C.; Ansell, S. M.; Link, B. K.; Riby, J.; North, K. E.; Gu, J.; Hjalgrim, H.; Cozen, W.; Becker, N.; Teras, L. R.; Spinelli, J. J.; Turner, J.; Zhang, Y. W.; Purdue, M. P.; Giles, G. G.; Kelly, R. S.; Zeleniuch-Jacquotte, A.; Ennas, M. G.; Monnereau, A.; Bertrand, K. A.; Albanes, D.; Lightfoot, T.; Yeager, M.; Chung, C. C.; Burdett, L.; Hutchinson, A.; Lawrence, C.; Montalvan, R.; Liang, L. M.; Huang, J. Y.; Ma, B.; Villano, D. J.; Maria, A.; Corines, M.; Thomas, T.; Novak, A. J.; Dogan, A.; Liebow, M.; Thompson, C. A.; Witzig, T. E.; Habermann, T. M.; Weiner, G. J.; Smith, M. T.; Holly, E. A.; Jackson, R. D.; Tinker, L. F.; Ye, Y.; Adami, H. O.; Smedby, K. E.; De Roos, A. J.; Hartge, P.; Morton, L. M.; Severson, R. K.; Benavente, Y.; Boffetta, P.; Brennan, P.; Foretova, L.; Maynadie, M.; McKay, J.; Staines, A.; Diver, W. R.; Vajdic, C. M.; Armstrong, B. K.; Kricker, A.; Zheng, T. Z.; Holford, T. R.; Severi, G.; Vineis, P.; Ferri, G. M.; Ricco, R.; Miligi, L.; Clavel, J.; Giovannucci, E.; Kraft, P.; Virtamo, J.; Smith, A.; Kane, E.; Roman, E.; Chiu, B. C. H.; Fraumeni, J. F.; Wu, X. F.; Cerhan, J. R.; Offit, K.; Chanock, S. J.; Rothman, N.; Nieters, A. |
| Article Title: | A genome-wide association study of marginal zone lymphoma shows association to the HLA region |
| Abstract: | Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility. |
| Keywords: | classification; development; follicular lymphoma; gene-expression; cell; non-hodgkin-lymphoma; susceptibility loci; rheumatoid-arthritis; risk loci; gastric lymphoma; epidemiologic research |
| Journal Title: | Nature Communications |
| Volume: | 6 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2015-01-08 |
| Start Page: | 5751 |
| Language: | English |
| ACCESSION: | WOS:000348646500001 |
| DOI: | 10.1038/ncomms6751 |
| PROVIDER: | wos |
| PMCID: | PMC4287989 |
| PUBMED: | 25569183 |
| Notes: | Article -- Source: Wos |
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