A genome-wide association study of marginal zone lymphoma shows association to the HLA region Journal Article


Authors: Vijai, J.; Wang, Z. M.; Berndt, S. I.; Skibola, C. F.; Slager, S. L.; De Sanjose, S.; Melbye, M.; Glimelius, B.; Bracci, P. M.; Conde, L.; Birmann, B. M.; Wang, S. S.; Brooks-Wilson, A. R.; Lan, Q.; de Bakker, P. I. W.; Vermeulen, R. C. H.; Portlock, C.; Ansell, S. M.; Link, B. K.; Riby, J.; North, K. E.; Gu, J.; Hjalgrim, H.; Cozen, W.; Becker, N.; Teras, L. R.; Spinelli, J. J.; Turner, J.; Zhang, Y. W.; Purdue, M. P.; Giles, G. G.; Kelly, R. S.; Zeleniuch-Jacquotte, A.; Ennas, M. G.; Monnereau, A.; Bertrand, K. A.; Albanes, D.; Lightfoot, T.; Yeager, M.; Chung, C. C.; Burdett, L.; Hutchinson, A.; Lawrence, C.; Montalvan, R.; Liang, L. M.; Huang, J. Y.; Ma, B.; Villano, D. J.; Maria, A.; Corines, M.; Thomas, T.; Novak, A. J.; Dogan, A.; Liebow, M.; Thompson, C. A.; Witzig, T. E.; Habermann, T. M.; Weiner, G. J.; Smith, M. T.; Holly, E. A.; Jackson, R. D.; Tinker, L. F.; Ye, Y.; Adami, H. O.; Smedby, K. E.; De Roos, A. J.; Hartge, P.; Morton, L. M.; Severson, R. K.; Benavente, Y.; Boffetta, P.; Brennan, P.; Foretova, L.; Maynadie, M.; McKay, J.; Staines, A.; Diver, W. R.; Vajdic, C. M.; Armstrong, B. K.; Kricker, A.; Zheng, T. Z.; Holford, T. R.; Severi, G.; Vineis, P.; Ferri, G. M.; Ricco, R.; Miligi, L.; Clavel, J.; Giovannucci, E.; Kraft, P.; Virtamo, J.; Smith, A.; Kane, E.; Roman, E.; Chiu, B. C. H.; Fraumeni, J. F.; Wu, X. F.; Cerhan, J. R.; Offit, K.; Chanock, S. J.; Rothman, N.; Nieters, A.
Article Title: A genome-wide association study of marginal zone lymphoma shows association to the HLA region
Abstract: Marginal zone lymphoma (MZL) is the third most common subtype of B-cell non-Hodgkin lymphoma. Here we perform a two-stage GWAS of 1,281 MZL cases and 7,127 controls of European ancestry and identify two independent loci near BTNL2 (rs9461741, P - 3.95 x 10(-15)) and HLA-B (rs2922994, P - 2.43 x 10(-9)) in the HLA region significantly associated with MZL risk. This is the first evidence that genetic variation in the major histocompatibility complex influences MZL susceptibility.
Keywords: classification; development; follicular lymphoma; gene-expression; cell; non-hodgkin-lymphoma; susceptibility loci; rheumatoid-arthritis; risk loci; gastric lymphoma; epidemiologic research
Journal Title: Nature Communications
Volume: 6
ISSN: 2041-1723
Publisher: Nature Publishing Group  
Date Published: 2015-01-08
Start Page: 5751
Language: English
ACCESSION: WOS:000348646500001
DOI: 10.1038/ncomms6751
PROVIDER: wos
PMCID: PMC4287989
PUBMED: 25569183
Notes: Article -- Source: Wos
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MSK Authors
  1. Kenneth Offit
    496 Offit
  2. Carol Portlock
    175 Portlock
  3. Vijai Joseph
    113 Joseph
  4. Marina Julia Corines
    13 Corines
  5. Tinu Mary Thomas
    15 Thomas
  6. Ahmet Dogan
    162 Dogan
  7. Danylo Julian Villano
    13 Villano
  8. Ann   Maria
    7 Maria