Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface Journal Article

Authors: Saha, N.; Kolev, M.; Nikolov, D. B.
Article Title: Structural features of the Nogo receptor signaling complexes at the neuron/myelin interface
Abstract: Upon spinal cord injury, the central nervous system axons are unable to regenerate, partially due to the repulsive action of myelin inhibitors, such as the myelin-associated glycoprotein (MAG), Nogo-A and the oligodendrocyte myelin glycoprotein (OMgp). These inhibitors bind and signal through a single receptor/co-receptor complex that comprises of NgR1/LINGO-1 and either p75 or TROY, triggering intracellular downstream signaling that impedes the re-growth of axons. Structure-function analysis of myelin inhibitors and their neuronal receptors, particularly the NgRs, have provided novel information regarding the molecular details of the inhibitor/receptor/co-receptor interactions. Structural and biochemical studies have revealed the architecture of many of these proteins and identified the molecular regions important for assembly of the inhibitory signaling complexes. It was also recently shown that gangliosides, such as GT1b, mediate receptor/co-receptor binding. In this review, we highlight these studies and summarize our current understanding of the multi-protein cell-surface complexes mediating inhibitory signaling events at the neuron/myelin interface. (C) 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society. All rights reserved.
Keywords: myelin; identification; inhibition; crystal-structure; cns; ganglioside; nogo receptor; neurite outgrowth; myelin-associated glycoprotein; axonal regeneration; homolog ngr2; lingo-1; chondroitin sulfate; neurotrophin receptor; associated glycoprotein; nogoa; chondroitin sulfate proteoglycans
Journal Title: Neuroscience Research
Volume: 87
ISSN: 0168-0102
Publisher: Elsevier Ireland Ltd.  
Date Published: 2014-10-01
Start Page: 1
End Page: 7
Language: English
ACCESSION: WOS:000347742600001
DOI: 10.1016/j.neures.2014.06.003
PUBMED: 24956133
Notes: Review -- Source: Wos
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MSK Authors
  1. Dimitar B Nikolov
    70 Nikolov
  2. Nayanendu Saha
    14 Saha
  3. Momchil V Kolev
    7 Kolev