Sentinel lymph node biopsy for cutaneous head and neck melanomas Journal Article
| Authors: | Patel, S. G.; Coit, D. G.; Shaha, A. R.; Brady, M. S.; Boyle, J. O.; Singh, B.; Shah, J. P.; Kraus, D. H. |
| Article Title: | Sentinel lymph node biopsy for cutaneous head and neck melanomas |
| Abstract: | Objective: To report the results of sentinel lymph node biopsy (SLNB) for cutaneous head and neck melanomas (CMHNs). Design: Consecutive series followed for a median of 20 months. Setting: Tertiary cancer care center. Patients: Fifty-six individuals with clinically nodenegative CMHN, median Breslow thickness, 2.6 mm (range, 0.2-20.0 mm). Interventions: Preoperative technetium 99m sulfur colloid lymphoscintigraphy (PLSG) followed within 4 hours by intraoperative handheld gamma probe localization (IHGP). Intraoperative injection of 1% isosulfan blue dye (IBD) was used in 48 patients. Immediate completion nodal dissection was performed for metastatic SLNs on intraoperative frozen section analysis and monitoring for negative SLNs. Main Outcome Measures: Rate of SLN identification, SLN and non-SLN positivity, same-basin recurrence, and disease-specific and recurrence-free survival. Results: Combination of IHGP and IBD improved SLN identification to 96% from 93% for IHGP and 73% for IBD alone. Four patients had a positive SLN on frozen section analysis. A negative SLNB correctly predicted regional nodal control in 47 of 48 patients but missed 1 of 5 patients who had regional lymphatic disease. All 4 patients who failed SLNB remain alive and free of recurrent disease. Two-year Kaplan-Meier disease-specific and relapse-free survival was 91% and 88%, respectively. Two-year disease-specific survival was 93% for SLN-negative patients and 50% for SLN-positive patients (P=.20). Conclusions: Combining PLSG with IHGP and IBD improves the success rate of SLNB. Although SLNB is a reliable indicator of the status of the draining lymphatic basins in CMHN, patients with negative SLNs must be observed for longer periods to understand the true implications of the procedure. |
| Keywords: | adolescent; adult; child; school child; aged; aged, 80 and over; middle aged; survival rate; major clinical study; cancer recurrence; conference paper; lymph node metastasis; lymph node dissection; isosulfan blue; lymphoscintigraphy; rosaniline dyes; sentinel lymph node biopsy; technetium tc 99m sulfur colloid; melanoma; skin neoplasms; head and neck cancer; head and neck neoplasms; frozen section; frozen sections; technetium sulfur colloid tc 99m; humans; human; male; female |
| Journal Title: | Archives of Otolaryngology - Head & Neck Surgery |
| Volume: | 128 |
| Issue: | 3 |
| ISSN: | 0886-4470 |
| Publisher: | American Medical Association |
| Date Published: | 2002-03-01 |
| Start Page: | 285 |
| End Page: | 291 |
| Language: | English |
| PUBMED: | 11886345 |
| PROVIDER: | scopus |
| DOI: | 10.1001/archotol.128.3.285 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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