Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma Journal Article
| Authors: | Stojadinovic, A.; Allen, P. J.; Clary, B. M.; Busam, K. J.; Coit, D. G. |
| Article Title: | Value of frozen-section analysis of sentinel lymph nodes for primary cutaneous malignant melanoma |
| Abstract: | Objective: To analyze a large, single-institution experience with routine frozen section (FS) of the sentinel lymph node (SLN) in patients with primary cutaneous melanoma. Summary Background Data: Controversy exists over the utility of intraoperative FS analysis of the SLN in patients with primary cutaneous melanoma. Methods: All patients with clinically node-negative cutaneous melanoma undergoing SLN biopsy from 1991 to 1999 were identified from a prospective database. All SLNs were examined by FS. Step-sectioning and immunohistochemistry of permanent section were performed for SLNs negative by FS. Results: At least one SLN was identified in 98% (360/368) of patients. There were 74 (20%) SLNs positive on permanent section; FS was positive in 59% of these. The accuracy, sensitivity, and specificity of FS were 92%, 59%, and 100%. Because isolated recurrence developed in six patients in the nodal basin in which the SLN was negative, the failure rate was 1.7%. The false-negative rate for SLN biopsy was 7.5%. Conclusions: Because the prevalence of metastases within the SLN and sensitivity of FS analysis are low, routine use of FS for all patients undergoing SLN biopsy is not recommended. |
| Keywords: | immunohistochemistry; adolescent; adult; child; controlled study; human tissue; aged; aged, 80 and over; middle aged; major clinical study; follow-up studies; lymphatic metastasis; prospective study; sensitivity and specificity; sentinel lymph node; lymph node excision; prospective studies; sentinel lymph node biopsy; treatment indication; accuracy; melanoma; skin neoplasms; time factors; data interpretation, statistical; reliability; frozen section; frozen sections; lymph node biopsy; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Annals of Surgery |
| Volume: | 235 |
| Issue: | 1 |
| ISSN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2002-01-01 |
| Start Page: | 92 |
| End Page: | 98 |
| Language: | English |
| DOI: | 10.1097/00000658-200201000-00012 |
| PUBMED: | 11753047 |
| PROVIDER: | scopus |
| PMCID: | PMC1422400 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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