Genetic modeling of glioma formation in mice Journal Article
| Authors: | Begemann, M.; Fuller, G. N.; Holland, E. C. |
| Article Title: | Genetic modeling of glioma formation in mice |
| Abstract: | In addition to the histological features that define gliomas, mutations and other alterations in gene expression and signal transduction are classically found in these tumors. Some of these alterations are likely to be the effects of the neoplastic phenotype, while others may be causative agents essential to the etiologic origin of the disease. The determination of whether specific genetic alterations, either individually or in combination, can serve as the etiology of gliomas requires modeling in animals with the fulfillment of Koch's postulates. Animal modeling studies not only provide information on the potential causes of glioma formation, they also identify novel candidate targets for therapy and provide tumorbearing animals for preclinical trials. Recently, remarkable strides have been made in the generation of mouse models of the diffuse gliomas that provide unparalleled opportunities for advancing our knowledge of the etiology, maintenance, and treatment of this lethal class of tumors. |
| Keywords: | signal transduction; gene mutation; nonhuman; conference paper; glioma; brain neoplasms; mouse; phenotype; animals; mice; gene targeting; cell cycle; gene expression; animal experiment; animal model; carcinogenesis; cell lineage; mice, transgenic; gene expression regulation, neoplastic; disease models, animal; genetic model |
| Journal Title: | Brain Pathology |
| Volume: | 12 |
| Issue: | 1 |
| ISSN: | 1015-6305 |
| Publisher: | Blackwell Publishing |
| Date Published: | 2002-01-01 |
| Start Page: | 117 |
| End Page: | 132 |
| Language: | English |
| PUBMED: | 11770894 |
| PROVIDER: | scopus |
| DOI: | 10.1111/j.1750-3639.2002.tb00428.x |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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