The utility of monoclonal antibodies in the imaging of prostate cancer Journal Article
| Authors: | Yao, D.; Trabulsi, E. J.; Kostakoglu, L.; Vallabhajosula, S.; Joyce, M. A.; Nanus, D. M.; Milowsky, M.; Liu, H.; Goldsmith, S. J. |
| Article Title: | The utility of monoclonal antibodies in the imaging of prostate cancer |
| Abstract: | Monoclonal antibodies (mAbs) to prostate-specific antigens, such as PSMA, have great potential as diagnostic and therapeutic tools in the management of advanced prostate cancer. PSMA is a very attractive target for mAb-based imaging. It is expressed by virtually all prostate cancers and its expression is further increased in poorly differentiated, metastatic, and hormone-refractory carcinomas. The ProstaScint scan (Cytogen, Princeton, NJ), based on the mAb 7E11-C5.3, is currently approved for the imaging of prostate cancer in soft tissue but is not approved for imaging bone metastases. It appears superior to conventional imaging studies for soft-tissue disease but has limitations attributed to its intracellular binding site on PSMA. Overcoming this limitation, new mAbs to the extracellular domain of PSMA have been developed. The radioisotopes, 111Indium, 90Yttrium, and 177Lutetium have been conjugated to one such mAb, J591. Radioimmunoscintigraphy with this immunoconjugate has demonstrated excellent tumor targeting of prostate cancer sites not only in soft tissue but also in bone. Copyright 2002, Elsevier Science (USA). All rights reserved. |
| Keywords: | review; cancer staging; antigen expression; prostate specific antigen; metastasis; diagnostic imaging; cancer resistance; monoclonal antibodies; monoclonal antibody; prostate cancer; prostatic neoplasms; soft tissue; capromab pendetide in 111; prostate specific membrane antigen; antibodies, monoclonal; indium radioisotopes; diagnostic value; bone; imaging; binding site; radioisotope; indium 111; radioisotopes; glutamate carboxypeptidase ii; antigens, surface; tomography, emission-computed; equipment; antibody conjugate; immunoconjugates; yttrium 90; lutetium; target organ; prostate-specific membrane antigen; immunoscintigraphy; humans; human; male; priority journal; carboxypeptidases |
| Journal Title: | Seminars in Urologic Oncology |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 1081-0943 |
| Publisher: | W.B. Saunders Co. |
| Date Published: | 2002-08-01 |
| Start Page: | 211 |
| End Page: | 218 |
| Language: | English |
| DOI: | 10.1053/suro.2002.36250 |
| PUBMED: | 12215974 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
