What messenger RNA capping tells us about eukaryotic evolution Journal Article
| Author: | Shuman, S. |
| Article Title: | What messenger RNA capping tells us about eukaryotic evolution |
| Abstract: | The 5′ cap is a unique feature of eukaryotic cellular and viral messenger RNA that is absent from the bacterial and archaeal domains of life. The cap is formed by three enzymatic reactions at the 5′ terminus of nascent mRNAs. Although the capping pathway is conserved in all eukaryotes, the structure and genetic organization of the component enzymes vary between species. These differences provide insights into the evolution of eukaryotes and eukaryotic viruses. |
| Keywords: | review; nonhuman; animals; gene function; evolution; enzyme activity; acid anhydride hydrolases; bacteria (microorganisms); correlation analysis; amino acid sequence; molecular sequence data; messenger rna; dna viruses; rna caps; sequence alignment; eukaryota; species difference; models, molecular; protein structure, tertiary; molecular structure; structure analysis; virus; protozoa; archaea; bacterium; protozoon; rna processing, post-transcriptional; fungal proteins; rna capping; eukaryotic cells; eukaryote evolution; plant proteins; priority journal |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 3 |
| Issue: | 8 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-08-01 |
| Start Page: | 619 |
| End Page: | 625 |
| Language: | English |
| DOI: | 10.1038/nrm880 |
| PUBMED: | 12154373 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
