| Abstract: |
The PML gene, involved in the t(15;17) chromosomal translocation of acute promyelocytic leukemia (APL), encodes a protein which localizes to the PML-nuclear body, a subnuclear macromolecular structure. PML controls apoptosis, cell proliferation, and senescence. Here, we review the current understanding of its role in tumor suppression. |
| Keywords: |
review; nonhuman; protein localization; neoplasms; cell proliferation; animals; cell division; apoptosis; neoplasm proteins; protein p53; carcinogenesis; transcription factors; cell transformation, neoplastic; nuclear proteins; cancer inhibition; intracellular signaling peptides and proteins; carrier proteins; tumor suppressor proteins; promyelocytic leukemia; oncogene proteins, fusion; adaptor proteins, signal transducing; tumor suppressor protein p53; genetic stability; chromosome translocation; chemical structure; senescence; cell aging; genes, tumor suppressor; biogenesis; receptors, retinoic acid; cell nucleus inclusion body; humans; human; priority journal
|
