Vascular and haematopoietic stem cells: Novel targets for anti-angiogenesis therapy? Journal Article
| Authors: | Rafii, S.; Lyden, D.; Benezra, R.; Hattori, K.; Heissig, B. |
| Article Title: | Vascular and haematopoietic stem cells: Novel targets for anti-angiogenesis therapy? |
| Abstract: | Tumours recruit neighbouring blood vessels and vascular endothelial cells to support their own blood supply. Recent evidence has indicated, however, that tumours are also capable of mobilizing bone-marrow-derived endothelial precursor cells, inducing them to migrate to the tumour and become incorporated into the developing vasculature. Tumour-derived angiogenic factors promote the recruitment of these cells, which include circulating endothelial progenitor cells and haematopoietic stem and progenitor cells. As clinical trials with anti-angiogenic agents have been confronted with therapeutic hurdles, inhibiting the recruitment of these vascular precursors might provide a novel approach to blocking tumour angiogenesis. |
| Keywords: | platelet derived growth factor; vasculotropin; intercellular signaling peptides and proteins; vascular endothelial growth factor a; unclassified drug; review; angiogenesis inhibitor; nonhuman; drug targeting; neoplasm; neoplasms; mouse; animal; mouse mutant; animals; mice; mice, knockout; bone marrow cells; stem cell factor; gelatinase b; granulocyte macrophage colony stimulating factor; neoplasm proteins; cell motion; cell differentiation; drug effect; pathology; vasculotropin inhibitor; vasculotropin receptor 2; angiogenesis; neovascularization, pathologic; vascular endothelial growth factor receptor-2; vascularization; physiology; cell lineage; stem cell; endothelium cell; vascular endothelium; endothelium, vascular; signal peptide; tumor protein; vasculotropin a; hematopoietic stem cells; neoplasms, experimental; cell migration; cell movement; blood vessel; forecasting; stem cells; bone marrow cell; hematopoietic stem cell; experimental neoplasm; vascular endothelial growth factor receptor-1; angiogenesis inhibitors; tumor vascularization; granulocyte colony stimulating factor; neovascularization (pathology); vasculotropin receptor 1; blood vessels; bone marrow toxicity; angiogenic factor; matrix metalloproteinase 9; vascular endothelial growth factors; endothelial growth factors; endothelial cell growth factor; humans; human; priority journal; lymphokines; lymphokine |
| Journal Title: | Nature Reviews Cancer |
| Volume: | 2 |
| Issue: | 11 |
| ISSN: | 1474-175X |
| Publisher: | Nature Publishing Group |
| Date Published: | 2002-11-01 |
| Start Page: | 826 |
| End Page: | 835 |
| Language: | English |
| DOI: | 10.1038/nrc925 |
| PUBMED: | 12415253 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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