Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells Journal Article
| Authors: | Rafii, D. C.; Psaila, B.; Butler, J.; Jin, D. K.; Lyden, D. |
| Article Title: | Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells |
| Abstract: | Bone marrow-derived cells contribute to physiological and pathological vascular remodeling throughout ontogenesis and adult life. During tissue regeneration and tumor growth, the release of cytokines and chemokines mediates the recruitment of hematopoietic and endothelial progenitor cells that contribute to the assembly of neovessels. Current evidence implies that platelets contribute structurally and instructively to vascular remodeling. Platelets adhere almost immediately to exposed or activated endothelium, and they are major storage and delivery vehicles for pro- and antiangiogenic growth factors including VEGF-A and thrombospondin (TSP), and cytokines and chemokines, such as stromal-derived factor 1 (SDF-1). By site-specific deployment of these factors, platelets orchestrate the local angiogenic stimulus within a tissue and direct the recruitment and differentiation of circulating bone marrow-derived cells. These insights have profound clinical implications; inhibition of platelet-deployed growth factors or their receptors may be an effective strategy to block tumor growth, whereas activation of these pathways may be used to accelerate revascularization and tissue regeneration. © 2008 American Heart Association, Inc. |
| Keywords: | protein expression; vascular endothelial growth factor a; janus kinase 2; review; nonhuman; protein function; phenotype; bone marrow cells; stem cell factor; gelatinase b; tissue regeneration; cell differentiation; vasculotropin receptor 2; angiogenesis; vasculotropin c; endothelial cells; enzyme phosphorylation; ischemia; vasculotropin a; bone marrow cell; hematopoietic stem cell; tumor growth; cytokine release; thrombospondin 1; neovascularization, physiologic; vasculotropin receptor 1; blood platelets; stromal cell derived factor 1; ontogeny; chemokine cxcl12; thrombospondin; hematopoietic progenitor cells; platelets; endothelial progenitor cells; stromal cell derived factor 1alpha; revascularization; thrombocyte adhesion; thrombospondins |
| Journal Title: | Arteriosclerosis Thrombosis and Vascular Biology |
| Volume: | 28 |
| Issue: | 2 |
| ISSN: | 1079-5642 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2008-02-01 |
| Start Page: | 217 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.1161/atvbaha.107.151159 |
| PUBMED: | 18096826 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 20" - "Export Date: 17 November 2011" - "CODEN: ATVBF" - "Source: Scopus" |
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