An update on epidermal growth factor receptor inhibitors Journal Article
| Authors: | Modi, S.; Seidman, A. D. |
| Article Title: | An update on epidermal growth factor receptor inhibitors |
| Abstract: | The epidermal growth factor receptor (EGFR) is part of a family of plasma membrane receptor tyrosine kinases that control many important cellular functions, from cell growth and proliferation to cell death. Dysregulation of the EGFR signal transduction pathway has been implicated in tumorigenesis and cancer progression, making it a clinically relevant target for novel anticancer treatments. This paper reviews recent progress in the development of cancer therapies that are directed toward particular aspects of the extracellular and intracellular domains of EGFR. Promising new compounds in the advanced stages of clinical testing are emphasized. |
| Keywords: | signal transduction; clinical trial; review; antineoplastic agents; research design; methodology; antineoplastic agent; neoplasm; neoplasms; animal; epidermal growth factor receptor; receptor, epidermal growth factor; drug effect; tumor cells, cultured; protein tyrosine kinase; monoclonal antibody; antibodies, monoclonal; cell culture; ligand; gene therapy; ligands; clinical trials; vaccine; vaccines; immunotoxin; immunotoxins; antibodies, bispecific; bispecific antibody; protein-tyrosine kinase; human |
| Journal Title: | Current Oncology Reports |
| Volume: | 4 |
| Issue: | 1 |
| ISSN: | 1523-3790 |
| Publisher: | Springer |
| Date Published: | 2002-02-01 |
| Start Page: | 47 |
| End Page: | 55 |
| Language: | English |
| PUBMED: | 11734113 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s11912-002-0047-6 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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