Expression of transforming growth factor-α and the epidermal growth factor receptor in human prostate tissues Journal Article

  


Authors: Cohen, D. W.; Simak, R.; Fair, W. R.; Melamed, J.; Scher, H. I.; Cordon-Cardo, C.
Article Title: Expression of transforming growth factor-α and the epidermal growth factor receptor in human prostate tissues
Abstract: Cells respond to certain soluble factors that bind to cell surface receptors possessing intrinsic tyrosine kinase activity. Overexpression of these molecules has been associated with tumor progression. Enhanced prostatic cancer cell growth in vitro has been reported in the presence of certain growth factors. To characterize the patterns of expression of the epidermal growth factor receptor (EGFr) and transforming growth factor-alpha (TGFα), we studied tissue from 107 prostate specimens using immunohistochemistry. We observed that epithelial cells of normal (n = 4) and benign prostatic (n = 56) tissues express EGFr but were unreactive for TGFα, while stroma cells in these tissues express TGFα but not EGFr. However, coexpression of EGFr and TGFα was identified in 22 of 46 prostatic adenocarcinomas studied. These results suggest that the major mode of action of EGFr/TGFα in normal and benign prostate is that of a paracrine or juxtacrine loop, the ligand being expressed in the stroma cells and the receptor in the epithelial cells. Since a subset of prostatic carcinomas coexpressed the ligand and the receptor in their tumor cells, it is suggested that an independent autocrine signaling mechanism may occur and grant a selective advantage for the growth of prostate cancers.
Keywords: immunohistochemistry; epidermal growth factor; human tissue; cancer growth; cancer staging; binding affinity; neoplasms; disease association; epidermal growth factor receptor; prostate cancer; prostate; prostate hypertrophy; receptor binding; transforming growth factor alpha; growth substances; human; priority journal; article
Journal Title: Journal of Urology
Volume: 152
Issue: 6 Pt. 1
ISSN: 0022-5347
Publisher: Elsevier Science, Inc.  
Date Published: 1994-12-01
Start Page: 2120
End Page: 2124
Language: English
DOI: 10.1016/s0022-5347(17)32335-2
PROVIDER: scopus
PUBMED: 7525998
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028090093&doi=10.1016%2fS0022-5347%2817%2932335-2&partnerID=40&md5=1bae848f772eb88356b99c418d9be0df
Notes: Export Date: 14 January 2019 -- Article -- CODEN: JOURA C2 -- Source: Scopus
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MSK Authors
  1. Carlos Cordon-Cardo
    612 Cordon-Cardo
  2. Howard Scher
    1130 Scher
  3. William R Fair
    342 Fair
  4. Jonathan Melamed
    22 Melamed
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