Access roads for RAG-ged terrains: Control of T cell receptor gene rearrangement at multiple levels Journal Article
| Authors: | Livák, F.; Petrie, H. T. |
| Article Title: | Access roads for RAG-ged terrains: Control of T cell receptor gene rearrangement at multiple levels |
| Abstract: | Antigen-specific immune response requires the generation of a diverse antigen (Ag)-receptor repertoire. The primary repertoire is generated through somatic gene rearrangement and molded by subsequent cellular selection. Constraints during gene recombination influence the ultimate shape of the repertoire. One major control mechanism of gene rearrangement, investigated for many years, is exerted through regulated chromosomal accessibility of the recombinase to the antigen receptor loci. More recent studies began to explore the role of interactions between the recombinase and its cognate recognition DNA sequences. The emerging results suggest that formation of the primary repertoire is controlled by two, partially independent factors: chromosomal accessibility and direct recombinase-DNA interactions. © 2002 Elsevier Science Ltd. All rights reserved. |
| Keywords: | review; nonhuman; animals; gene locus; t lymphocyte receptor; dna; gene rearrangement; genetic recombination; recombination, genetic; molecular recognition; antigen recognition; t-cell antigen receptor specificity; gene control; dna sequence; vdj recombinases; lymphocyte antigen receptor; cell selection; protein dna interaction; gene rearrangement, t-lymphocyte; recombinase; dna nucleotidyltransferases; accessibility; genes, rag-1; chromatin modification; humans; human; recombination signal sequence; t cell antigen receptor |
| Journal Title: | Seminars in Immunology |
| Volume: | 14 |
| Issue: | 5 |
| ISSN: | 1044-5323 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2002-10-01 |
| Start Page: | 297 |
| End Page: | 309 |
| Language: | English |
| DOI: | 10.1016/s1044-5323(02)00063-5 |
| PUBMED: | 12220931 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
