Fluoropyrimidine resistance in colon cancer Journal Article
| Authors: | Gorlick, R.; Banerjee, D. |
| Article Title: | Fluoropyrimidine resistance in colon cancer |
| Abstract: | A significant obstacle for the management of patients with colorectal cancer is intrinsic drug resistance or in patients that respond to chemotherapy, acquired drug resistance. Drug resistance can occur through a variety of mechanisms. These include alterations in drug influx, drug efflux, intracellular metabolic activation, intracellular catabolism, through alterations in the drug's target or through numerous changes downstream of the target including alterations in genes involved in the regulation of the cell cycle, apoptosis or in DNA damage repair. In this article, the mechanisms of action and the mechanisms of resistance to the fluoropyrimidines are reviewed focusing on newer studies using tumor samples obtained from patients. Clinical trials that can potentially overcome the relevant mechanisms of resistance are described. |
| Keywords: | controlled study; gene mutation; genetics; mutation; clinical trial; review; fluorouracil; antineoplastic agents; drug targeting; methotrexate; antineoplastic agent; colorectal cancer; metabolism; dna damage; cell cycle; dna repair; apoptosis; controlled clinical trial; antimetabolites, antineoplastic; colonic neoplasms; drug effect; drug resistance; drug resistance, neoplasm; pyrimidines; cancer research; irinotecan; drug mechanism; colon tumor; drug response; drug metabolism; pyrimidine derivative; thymidylate synthase; floxuridine; antineoplastic antimetabolite; 5-fluorouracil; drug transport; fluoropyrimidine derivative; thymidine phosphorylase; dihydropyrimidine dehydrogenase; fluorodeoxyuridine; humans; human; article; trinotecan; uridine monophosphate kinase |
| Journal Title: | Expert Review of Anticancer Therapy |
| Volume: | 2 |
| Issue: | 4 |
| ISSN: | 1473-7140 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2002-08-01 |
| Start Page: | 409 |
| End Page: | 416 |
| Language: | English |
| PUBMED: | 12647984 |
| PROVIDER: | scopus |
| DOI: | 10.1586/14737140.2.4.409 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
