Lymphomatous meningitis: Incidence, prognosis and treatment Journal Article
| Authors: | Chamberlain, M. C.; Nolan, C. P.; Abrey, L. E. |
| Article Title: | Lymphomatous meningitis: Incidence, prognosis and treatment |
| Abstract: | Lymphomatous meningitis (LM) is a common problem in neuro-oncology, occurring in approximately 5% of all patients with systemic lymphoma. Notwithstanding frequent focal signs and symptoms in LM, LM is a disease affecting the entire neuraxis and therefore staging and treatment need to encompass all cerebrospinal fluid (CSF) compartments. CNS staging of LM includes contrast enhanced cranial computerized tomography (CE-CT) or magnetic resonance imaging (MR-Gd), contrast enhanced spine magnetic resonance imaging (MR-S) or computerized tomographic myelography (CT-M) and radionuclide CSF flow study. Treatment of LM includes involved-field radiotherapy of bulky or symptomatic disease sites and intrathecal chemotherapy (intra-CSF) drug therapy. The inclusion of concomitant systemic therapy (high dose methotrexate or cytarabine) may benefit patients with LM and may obviate the need for intra-CSF chemotherapy. At present, intra-CSF drug therapy is confined to three chemotherapy agents (i.e. methotrexate, cytarabine and thiotepa) administered by a variety of schedules either by intralumbar or intraventricular drug delivery. Although treatment of LM is palliative, with an expected median patient survival of 6-10 months, it often affords stabilization and protection from further neurologic deterioration. |
| Keywords: | survival; cancer chemotherapy; clinical feature; clinical trial; review; interferon; cancer radiotherapy; cytarabine; gadolinium; methotrexate; drug megadose; nuclear magnetic resonance imaging; neurosurgery; interleukin 2; computer assisted tomography; incidence; thiotepa; monoclonal antibody; cerebrospinal fluid; contrast enhancement; nerve fiber; lymphoma; meningitis; drug delivery system; cerebrospinal fluid flow; diaziquone; myelography; mafosfamide; 4 hydroperoxycyclophosphamide; lymphomatous meningitis; prognosis; human; priority journal; depo cyt |
| Journal Title: | American Journal of Cancer |
| Volume: | 1 |
| Issue: | 6 |
| ISSN: | 1175-6357 |
| Publisher: | Springer |
| Date Published: | 2002-11-01 |
| Start Page: | 423 |
| End Page: | 434 |
| Language: | English |
| DOI: | 10.2165/00024669-200201060-00005 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work