Updates on LI-RADS treatment response criteria for hepatocellular carcinoma: Focusing on MRI Review
| Authors: | Patel, R.; Aslam, A.; Parikh, N. D.; Mervak, B.; Mubarak, E.; Higgins, L.; Lala, K.; Conner, J. F.; Khaykin, V.; Bashir, M.; Do, R. K. G.; Burke, L. M. B.; Smith, E. N.; Kim, C. Y.; Shampain, K. L.; Owen, D.; Mendiratta-Lala, M. |
| Review Title: | Updates on LI-RADS treatment response criteria for hepatocellular carcinoma: Focusing on MRI |
| Abstract: | As the incidence of hepatocellular carcinoma (HCC) and subsequent treatments with liver-directed therapies rise, the complexity of assessing lesion response has also increased. The Liver Imaging Reporting and Data Systems (LI-RADS) treatment response algorithm (LI-RADS TRA) was created to standardize the assessment of response after locoregional therapy (LRT) on contrast-enhanced CT or MRI. Originally created based on expert opinion, these guidelines are currently undergoing revision based on emerging evidence. While many studies support the use of LR-TRA for evaluation of HCC response after thermal ablation and intra-arterial embolic therapy, data suggest a need for refinements to improve assessment after radiation therapy. In this manuscript, we review expected MR imaging findings after different forms of LRT, clarify how to apply the current LI-RADS TRA by type of LRT, explore emerging literature on LI-RADS TRA, and highlight future updates to the algorithm. Evidence Level: 3. Technical Efficacy: Stage 2. © 2023 International Society for Magnetic Resonance in Medicine. |
| Keywords: | retrospective studies; hepatocellular carcinoma; liver cell carcinoma; carcinoma, hepatocellular; liver neoplasms; nuclear magnetic resonance imaging; magnetic resonance imaging; sensitivity and specificity; diagnostic imaging; retrospective study; liver tumor; contrast medium; contrast media; procedures; locoregional therapy; data system; humans; human; treatment response assessment; liver imaging data and reporting system treatment response algorithm; data systems |
| Journal Title: | Journal of Magnetic Resonance Imaging |
| Volume: | 57 |
| Issue: | 6 |
| ISSN: | 1053-1807 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2023-06-01 |
| Start Page: | 1641 |
| End Page: | 1654 |
| Language: | English |
| DOI: | 10.1002/jmri.28659 |
| PUBMED: | 36872608 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PDF and PubMed -- Export Date: 31 May 2023 -- Source: Scopus |
