Reliability of maximal cardiopulmonary exercise testing in men with prostate cancer Journal Article


Authors: Scott, J. M.; Hornsby, W. E.; Lane, A.; Kenjale, A. A.; Eves, N. D.; Jones, L. W.
Article Title: Reliability of maximal cardiopulmonary exercise testing in men with prostate cancer
Abstract: Purpose To accurately assess exercise interventions and to evaluate acute and chronic cardiovascular effects in patients with early-stage cancer, consistently reliable functional outcome measures must be obtained. An incremental cardiopulmonary exercise test (CPET) with gas exchange measurement to assess peak oxygen consumption (VO2peak) provides the gold standard outcome of cardiorespiratory fitness. Methods In the context of a randomized controlled trial, 40 patients with prostate cancer (mean age, 59 7 yr) after radical prostatectomy performed two maximal CPET within 5.6 5.5 d of each other. Incremental treadmill tests were performed in the morning under identical laboratory conditions. Reliability and within-subject variability from test 1 to test 2 for peak and submaximal variables were assessed by correlation coefficients, intraclass correlations (ICC), Bland-Altman plots, coefficient of variation, and paired t-tests. Results There was high reliability between CPET for VO2peak (r = 0.92; P < 0.001; ICC, 0.900), ventilatory threshold (r = 0.88; P < 0.001; ICC, 0.927), minute ventilation-carbon dioxide production relation (V-E/VCO2) (r = 0.86; P < 0.001; ICC, 0.850), and peak heart rate (r = 0.95; P < 0.001; ICC, 0.944). However, high within-subject variability was observed for all CPET parameters (mean coefficient of variation, 4.7%). Compared with those for test 1, significantly higher mean values were observed for VO2peak (27.0 +/- 5.6 vs 28.1 +/- 5.3 mLkg(-1)min(-1), P < 0.05), ventilatory threshold (1.91 +/- 0.5 vs 1.97 +/- 0.4 Lmin(-1), P < 0.05), and V-E/VCO2 (31.3 +/- 5.8 vs 32.8 +/- 3.4, P < 0.05) in test 2. Conclusions These findings indicate the presence of significant, and potentially clinically important, variability in CPET procedures in men with clinically localized prostate cancer and have important implications for the application and use of CPET to evaluate the efficacy of interventions to improve aerobic capacity in the oncology setting.
Keywords: reproducibility; oncology; prostate cancer; prostatectomy; breast-cancer; quality-of-life; lung-cancer; radical; association; physical-activity; heart-failure; peak oxygen-consumption; test reproducibility; cardiovascular fitness; cardiac-failure
Journal Title: Medicine and Science in Sports and Exercise
Volume: 47
Issue: 1
ISSN: 0195-9131
Publisher: Lippincott Williams & Wilkins  
Date Published: 2015-01-01
Start Page: 27
End Page: 32
Language: English
ACCESSION: WOS:000346354800005
DOI: 10.1249/mss.0000000000000370
PROVIDER: wos
PUBMED: 24781891
PMCID: PMC4376254
Notes: Article -- Source: Wos
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  1. Lee Winston Jones
    133 Jones