Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3+4 prostate cancer Journal Article

   

Authors:	Gondo, T.; Poon, B. Y.; Matsumoto, K.; Bernstein, M.; Sjoberg, D. D.; Eastham, J. A.
Article Title:	Clinical role of pathological downgrading after radical prostatectomy in patients with biopsy confirmed Gleason score 3+4 prostate cancer
Abstract:	Objective To identify preoperative factors predicting Gleason score downgrading after radical prostatectomy (RP) in patients with biopsy Gleason score 3+4 prostate cancer and to determine if prediction of downgrading can identify potential candidates for active surveillance (AS). Patients and Methods We identified 1317 patients with biopsy Gleason score 3+4 prostate cancers who underwent RP at the Memorial Sloan-Kettering Cancer Center between 2005 and 2013. Several preoperative and biopsy characteristics were evaluated by forward selection regression, and selected predictors of downgrading were analysed by multivariable logistic regression. Decision curve analysis was used to evaluate the clinical utility of the multivariate model. Results Gleason score was downgraded after RP in 115 patients (9%). We developed a multivariable model using age, prostate-specific antigen density, percentage of positive cores with Gleason pattern 4 cancer out of all cores taken, and maximum percentage of cancer involvement within a positive core with Gleason pattern 4 cancer. The area under the curve for this model was 0.75 after 10-fold cross validation. However, decision curve analysis revealed that the model was not clinically helpful in identifying patients who will downgrade at RP for the purpose of reassigning them to AS. Conclusion While patients with pathological Gleason score 3 + 3 with tertiary Gleason pattern <= 4 at RP in patients with biopsy Gleason score 3 + 4 prostate cancer may be potential candidates for AS, decision curve analysis showed limited utility of our model to identify such men. Future study is needed to identify new predictors to help identify potential candidates for AS among patients with biopsy confirmed Gleason score 3 + 4 prostate cancer.
Keywords:	prostatic neoplasms; prostate; prostatectomy; active surveillance; experience; outcomes; surveillance; men; specimens; decision curve analysis; grading system; intermediate; active; low-risk; downgrading
Journal Title:	BJU International
Volume:	115
Issue:	1
ISSN:	1464-4096
Publisher:	Wiley Blackwell
Date Published:	2015-01-01
Start Page:	81
End Page:	86
Language:	English
ACCESSION:	WOS:000346651400017
DOI:	10.1111/bju.12769
PROVIDER:	wos
PMCID:	PMC4194186
PUBMED:	24725760
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/67384