Mechanism and regulation of meiotic recombination initiation Journal Article
| Authors: | Lam, I.; Keeney, S. |
| Article Title: | Mechanism and regulation of meiotic recombination initiation |
| Abstract: | Meiotic recombination involves the formation and repair of programmed DNA double-strand breaks (DSBs) catalyzed by the conserved Spo11 protein. This review summarizes recent studies pertaining to the formation of meiotic DSBs, including the mechanism of DNA cleavage by Spo11, proteins required for break formation, and mechanisms that control the location, timing, and number of DSBs. Where appropriate, findings in different organisms are discussed to highlight evolutionary conservation or divergence. |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2015-01-01 |
| Start Page: | a016634 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a016634 |
| PROVIDER: | scopus |
| PUBMED: | 25324213 |
| PMCID: | PMC4292169 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
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