Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion Journal Article

   


Authors: Gupta, M. P.; Coombs, P.; Prockop, S. E.; Hasan, A.; Doubrovina, E.; O'Reilly, R. J.; Cohen, S. H.; Park, S. S.; Kiss, S.
Article Title: Treatment of cytomegalovirus retinitis with cytomegalovirus-specific T-lymphocyte infusion
Abstract: Cytomegalovirus (CMV) retinitis is a potentially blinding infection that affects immunocompromised patients who are unable to generate a T-cell response against the organism. Infusion of CMV-specific leukocytes has been shown to be effective in patients with systemic CMV infection, especially those resistant to standard therapies. The authors report a case of a patient with CMV viremia with progressive retinitis in whom infusion of third-party donor-derived CMV pp65-specific T cells alone prompted resolution of CMV retinitis. This case suggests a potential role for CMV-specific leukocyte infusion in the treatment of CMV retinitis, especially in cases resistant or refractory to antiviral therapies.
Keywords: treatment outcome; case report; t lymphocyte; donor lymphocyte infusion; cytomegalovirus antigen pp65; human; priority journal; article; cytomegalovirus retinitis; cytomegalovirus specific t lymphocyte infusion
Journal Title: Ophthalmic Surgery Lasers and Imaging Retina
Volume: 46
Issue: 1
ISSN: 2325-8160
Publisher: Healio  
Date Published: 2015-01-01
Start Page: 80
End Page: 82
Language: English
DOI: 10.3928/23258160-20150101-14
PROVIDER: scopus
PUBMED: 25559515
PMCID: PMC4373317
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84920725098&partnerID=40&md5=574387ff9adbe2a91c831b461adefeaa
Notes: Export Date: 2 February 2015 -- Source: Scopus
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MSK Authors
  1. Susan E Prockop
    262 Prockop
  2. Ekaterina Doubrovina
    101 Doubrovina
  3. Aisha Nasreen Hasan
    56 Hasan
  4. Richard O'Reilly
    748 O'Reilly
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