Case Report: Cytomegalovirus-specific T-lymphocyte infusion for resistant cytomegalovirus retinitis Journal Article

   


Authors: Saban, T.; Shargian, L.; Eiger-Moscovitch, M.; Prockop, S.; Doubrovina, E.; Yeshurun, M.; Kramer, M.
Article Title: Case Report: Cytomegalovirus-specific T-lymphocyte infusion for resistant cytomegalovirus retinitis
Abstract: Purpose: We hereby describe a case of persistent cytomegalovirus (CMV) viremia and retinitis following allogeneic hematopoietic cell transplantation (HCT) that was successfully treated with infusion of CMV-specific cytotoxic T lymphocytes (CTL) despite previous treatment with Epstein Bar Virus (EBV) -specific CTL, which occurred 5 months earlier. Observations: Following several anti- viral medication treatment trials that failed to eradicate the infectious process, the patient was treated with infusions of CMV-CTL from a biobank of cryopreserved virus-specific cells. Shortly after the first infusion, a remarkable response was noted. A few days after the second infusion, the retinitis resolved completely. No recurrence was noted at the one-year follow-up, and there was no evidence of GVHD. Conclusions and importance: The case is unique for two reasons: use of virus-specific CTL for an indication of CMV retinitis; and successive administration, in the same patient, of third-party virus-specific CTL to treat two different infections (Epstein-Barr virus and cytomegalovirus) on two separate occasions following hematopoietic cell transplantation. Copyright © 2023 Saban, Shargian, Eiger-Moscovitch, Prockop, Doubrovina, Yeshurun and Kramer.
Keywords: cmv retinitis; cmv-specific cytotoxic t lymphocytes; cytomegalovirus-specific t-lymphocyte; resistant cmv retinitis; t-lymphocytes infusion
Journal Title: Frontiers in Ophthalmology
Volume: 3
ISSN: 2674-0826
Publisher: Frontiers Research Foundation  
Date Published: 2023-07-03
Start Page: 1131674
Language: English
DOI: 10.3389/fopht.2023.1131674
PROVIDER: scopus
PMCID: PMC11182297
PUBMED: 38983025
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85183619572&doi=10.3389%2ffopht.2023.1131674&partnerID=40&md5=281b0d6f19cb66b7a2ad25c58f9f2225
Notes: Article -- Source: Scopus
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MSK Authors
  1. Susan E Prockop
    262 Prockop
  2. Ekaterina Doubrovina
    101 Doubrovina
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