Dilemmas in treating smoldering multiple myeloma Journal Article

Authors: Ahn, I. E.; Mailankody, S.; Korde, N.; Landgren, O.
Article Title: Dilemmas in treating smoldering multiple myeloma
Abstract: Novel therapies hold promise for high-risk smoldering multiple myeloma (SMM). Recent studies suggest that modern combination approaches can be options for high-risk SMM to obtain deep molecular responses with favorable toxicity profiles. Although pioneering treatment trials based on small numbers of patients suggest progression-free and overall survival benefits, application of the data to real-life practice remains to be validated. Therapeutic modulation of disease tempo, disease burden, clonal evolution, and tumor microenvironment in SMM remains to be understood and calls for reliable biomarkers reflective of disease biology. Here, we review studies that open a new management platform for SMM, address ongoing dilemmas in practice and under investigation, and highlight emerging scientific questions in the era of SMM treatment.
Keywords: treatment response; thalidomide; pathogenesis; review; cancer risk; clinical practice; multiple myeloma; bisphosphonic acid derivative; melphalan; malignant transformation; smoldering multiple myeloma; human
Journal Title: Journal of Clinical Oncology
Volume: 33
Issue: 1
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2015-01-01
Start Page: 115
End Page: 123
Language: English
DOI: 10.1200/jco.2014.56.4351
PROVIDER: scopus
PMCID: PMC4268248
PUBMED: 25422486
Notes: Export Date: 2 February 2015 -- Source: Scopus
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MSK Authors
  1. Carl Ola Landgren
    175 Landgren
  2. Neha Sanat Korde
    56 Korde