The road to treating smoldering multiple myeloma Conference Paper
| Authors: | Korde, N.; Mailankody, S.; Landgren, O. |
| Title: | The road to treating smoldering multiple myeloma |
| Conference Title: | 2013 SOHO Annual Meeting |
| Abstract: | The management of smoldering multiple myeloma (SMM) has been a challenge to clinicians, ever since the condition was first characterized in 1980. While the risk of progression to symptomatic myeloma is greater for SMM (10% per year) compared to MGUS (1% per year), several SMM patients remain asymptomatic for years without evidence of disease progression. Early clinical trials focusing on early treatment of SMM have been equivocal with no clear benefit. However, the last decade has seen a greater understanding of the pathogenesis of plasma cell disorders, including SMM, and development of better therapeutics. A recent randomized trial has provided evidence of clinical benefit with early treatment of high-risk SMM. In this review, we summarize issues related to the early treatment of SMM including risk stratification and possible outcomes with therapy initiation. In the context of reviewing recent clinical trial data supporting early treatment, we define challenges faced by clinicians and provide future directions to the road to treating SMM. |
| Keywords: | lenalidomide; dexamethasone; risk; minimal residual disease; progression; plasma cells; long-term; disease; stage-i; undetermined significance mgus; monoclonal gammopathy; multiparameter flow-cytometry; high-risk smm; mgus; monoclonal protein |
| Journal Title | Clinical Lymphoma, Myeloma and Leukemia |
| Volume: | 14 |
| Issue: | Suppl. |
| Conference Dates: | 2013 Sep 18-21 |
| Conference Location: | Houston, TX |
| ISBN: | 2152-2650 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-09-01 |
| Start Page: | S59 |
| End Page: | S64 |
| Language: | English |
| ACCESSION: | WOS:000346949500010 |
| DOI: | 10.1016/j.clml.2014.04.012 |
| PROVIDER: | wos |
| Notes: | Article -- 3 -- Source: Wos |
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