Homotypic receptor-receptor interactions regulating Eph signaling Journal Article


Authors: Nikolov, D. B.; Xu, K.; Himanen, J. P.
Article Title: Homotypic receptor-receptor interactions regulating Eph signaling
Abstract: The Eph receptor tyrosine kinases and their ephrin ligands direct axon pathfinding and neuronal cell migration, and mediate many other cell-cell communication events. The Ephs and ephrins both localize to the plasma membrane and, upon cell-cell contact, form extensive signaling assemblies at the contact sites. Recent structural, biochemical and cell-biological studies revealed that these assemblies are generated not only via Eph-ephrin interactions, but also via homotypic interactions between neighboring receptor molecules. In addition, Eph-Eph interactions mediate receptor pre-clustering, which ensures fast and efficient activation once ligands come into contact range. Here we summarize the current knowledge about the homotypic Eph-Eph interactions and discuss how they could modulate the initiation of Eph/ephrin signaling.
Keywords: review; protein protein interaction; ligand; crystal structure; dimerization; molecular interaction; ligand binding; mutagenesis; cell contact; ephrin receptor
Journal Title: Cell Adhesion & Migration
Volume: 8
Issue: 4
ISSN: 1933-6918
Publisher: Landes Bioscience  
Date Published: 2014-07-04
Start Page: 360
End Page: 365
Language: English
DOI: 10.4161/19336918.2014.971684
PROVIDER: scopus
PUBMED: 25530219
PMCID: PMC4594565
DOI/URL:
Notes: Export Date: 2 February 2015 -- Source: Scopus
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MSK Authors
  1. Dimitar B Nikolov
    73 Nikolov
  2. Juha P Himanen
    43 Himanen
  3. Kai Xu
    20 Xu
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