Homotypic receptor-receptor interactions regulating Eph signaling Journal Article
| Authors: | Nikolov, D. B.; Xu, K.; Himanen, J. P. |
| Article Title: | Homotypic receptor-receptor interactions regulating Eph signaling |
| Abstract: | The Eph receptor tyrosine kinases and their ephrin ligands direct axon pathfinding and neuronal cell migration, and mediate many other cell-cell communication events. The Ephs and ephrins both localize to the plasma membrane and, upon cell-cell contact, form extensive signaling assemblies at the contact sites. Recent structural, biochemical and cell-biological studies revealed that these assemblies are generated not only via Eph-ephrin interactions, but also via homotypic interactions between neighboring receptor molecules. In addition, Eph-Eph interactions mediate receptor pre-clustering, which ensures fast and efficient activation once ligands come into contact range. Here we summarize the current knowledge about the homotypic Eph-Eph interactions and discuss how they could modulate the initiation of Eph/ephrin signaling. |
| Keywords: | review; protein protein interaction; ligand; crystal structure; dimerization; molecular interaction; ligand binding; mutagenesis; cell contact; ephrin receptor |
| Journal Title: | Cell Adhesion & Migration |
| Volume: | 8 |
| Issue: | 4 |
| ISSN: | 1933-6918 |
| Publisher: | Landes Bioscience |
| Date Published: | 2014-07-04 |
| Start Page: | 360 |
| End Page: | 365 |
| Language: | English |
| DOI: | 10.4161/19336918.2014.971684 |
| PROVIDER: | scopus |
| PUBMED: | 25530219 |
| PMCID: | PMC4594565 |
| DOI/URL: | |
| Notes: | Export Date: 2 February 2015 -- Source: Scopus |
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