Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation Journal Article
| Authors: | Nikolov, D. B.; Xu, K.; Himanen, J. P. |
| Article Title: | Eph/ephrin recognition and the role of Eph/ephrin clusters in signaling initiation |
| Abstract: | The Eph receptors and their ephrin ligands play crucial roles in a large number of cell-cell interaction events, including those associated with axon pathfinding, neuronal cell migration and vasculogenesis. They are also involved in the patterning of most tissues and overall cell positioning in the development of the vertebrate body plan. The Eph/ephrin signaling system manifests several unique features that differentiate it from other receptor tyrosine kinases, including initiation of bi-directional signaling cascades and the existence of ligand and receptor subclasses displaying promiscuous intra-subclass interactions, but very rare inter-subclass interactions. In this review we briefly discuss these features and focus on recent studies of the unique and expansive high-affinity Eph/ephrin assemblies that form at the sites of cell-cell contact and are required for Eph signaling initiation. This article is part of a Special Issue entitled: Emerging recognition and activation mechanisms of receptor tyrosine kinases. © 2013 Elsevier B.V. |
| Keywords: | signal transduction; vasculotropin; protein expression; protein phosphorylation; review; nonhuman; neoplasm; cell proliferation; metastasis; cluster analysis; confocal microscopy; signaling; cell protein; cell line; protein binding; protein tyrosine kinase; tyrosine; angiogenesis; b lymphocyte; vertebrata; gene expression regulation; molecular recognition; nerve fiber; escherichia coli; membrane protein; cell migration; cell movement; ligands; models, molecular; receptor; protein tyrosine phosphatase; ephrin receptor a2; protein structure; cell interaction; cell adhesion; cell communication; nerve cell; vertebrate; ephrin receptor b2; oligomerization; receptors, eph family; fibroblast growth factor receptor 1; ephrin; cell surface; stromal cell derived factor 1; cells; kinase; eph; n methyl dextro aspartic acid receptor; dephosphorylation; chemokine receptor cxcr4; micelle; ephrins; calcineurin; diacylglycerol kinase; ephrin receptor; ephrin a5; ephrin receptor a3; membrane enzyme; dimenhydrinate |
| Journal Title: | Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics |
| Volume: | 1834 |
| Issue: | 10 |
| ISSN: | 1570-9639 |
| Publisher: | Elsevier B.V. |
| Date Published: | 2013-10-01 |
| Start Page: | 2160 |
| End Page: | 2165 |
| Language: | English |
| DOI: | 10.1016/j.bbapap.2013.04.020 |
| PROVIDER: | scopus |
| PMCID: | PMC3777820 |
| PUBMED: | 23628727 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 October 2013" - "CODEN: BBAPB" - "Source: Scopus" |
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