| Abstract: |
Malignant, fibroadenoma, normal and adipose breast tissues were studied using diffuse reflectance spectroscopy. The absorption spectra of the breast tissues were extracted from the diffuse reflectance spectra using the Kubelka-Munk function (K-M function). The spectral features of the K-M function were identified and compared with those of the absorption spectra. The spectral features of the K-M function were assigned to DNA, protein, β-carotene and hemoglobin (oxygenated and deoxygenated) molecules in the breast tissue. The amplitudes of the K-M function averaged from 275 to 285 nm and from 255 to 265 nm and were found to be different for malignant, fibroadenoma and normal tissues. These differences were attributed to changes in proteins and DNA. A set of critical parameters was determined for separating malignant tissues from fibroadenoma and normal tissues. This approach should hold for other tissue types such as cervix, uterus and colon. |
| Keywords: |
human tissue; major clinical study; methodology; proteins; metabolism; breast cancer; adenocarcinoma, mucinous; neoplasm proteins; protein; hemoglobin; breast neoplasms; dna; breast tumor; breast carcinoma; tumor protein; dna, neoplasm; lung carcinoma; colloid carcinoma; fibroadenoma; spectroscopy; paget nipple disease; beta carotene; absorption spectroscopy; adipose tissue; breast diseases; breast disease; carcinoma, ductal, breast; carcinoma, lobular; chromatophore; breast fibroadenoma; dna protein complex; fibrocystic breast disease; spectrophotometry; diffuse reflectance spectroscopy; humans; human; female; article
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