BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors Journal Article
| Authors: | Timmer, J.; Wang, C.; Niswander, L. |
| Article Title: | BMP signaling patterns the dorsal and intermediate neural tube via regulation of homeobox and helix-loop-helix transcription factors |
| Abstract: | In the spinal neural tube, populations of neuronal precursors that express a unique combination of transcription factors give rise to specific classes of neurons at precise locations along the dorsoventral axis. Understanding the patterning mechanisms that generate restricted gene expression along the dorsoventral axis is therefore crucial to understanding the creation of diverse neural cell types. Bone morphogenetic proteins (BMPs) and other transforming growth factor β (TGFβ) proteins are expressed by the dorsal-most cells of the neural tube (the roofplate) and surrounding tissues, and evidence indicates that they play a role in assigning cell identity. We have manipulated the level of BMP signaling in the chicken neural tube to show that BMPs provide patterning information to both dorsal and intermediate cells. BMP regulation of the expression boundaries of the homeobox proteins Pax6, Dbx2 and Msx1 generates precursor populations with distinct developmental potentials. Within the resulting populations, thresholds of BMP act to set expression domain boundaries of developmental regulators of the homeobox and basic helix-loop-helix (bHLH) families, ultimately leading to the generation of a diversity of differentiated neural cell types. This evidence strongly suggests that BMPs are the key regulators of dorsal cell identity in the spinal neural tube. |
| Keywords: | signal transduction; controlled study; protein expression; mutation; dna-binding proteins; nonhuman; animals; bone morphogenetic protein; embryo; animal experiment; animal model; basic helix-loop-helix transcription factors; nerve tissue proteins; transcription factor; embryo pattern formation; cell differentiation; eye proteins; homeodomain proteins; neurons; cell population; cell type; animalia; transcription factors; stem cell; gene expression regulation, developmental; growth regulation; transcription factor pax6; homeodomain protein; nerve cell differentiation; repressor proteins; nerve cell; body patterning; neural tube; paired box transcription factors; receptors, cell surface; chick embryo; bone morphogenetic proteins; nervous system; receptors, growth factor; chick; chicken; pax7 transcription factor; homeobox; helix loop helix protein; dorsal-ventral patterning; bone morphogenetic protein receptors; avian proteins; helix-loop-helix motifs; priority journal; article; gallus gallus; basic helix-loop-helix; msx1 transcription factor |
| Journal Title: | Development |
| Volume: | 129 |
| Issue: | 10 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2002-05-01 |
| Start Page: | 2459 |
| End Page: | 2472 |
| Language: | English |
| PUBMED: | 11973277 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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