Gastric surgical adjuvant radiotherapy consensus report: Rationale and treatment implementation Journal Article
| Authors: | Smalley, S. R.; Gunderson, L.; Tepper, J.; Martenson, J. A. Jr; Minsky, B.; Willett, C.; Rich, T. |
| Article Title: | Gastric surgical adjuvant radiotherapy consensus report: Rationale and treatment implementation |
| Abstract: | Purpose: Radiation therapy has recently emerged as a pivotal modality in the management of completely resected, high-risk gastric cancer. The recently published results of the Intergroup 0116 Gastric Surgical Adjuvant Trial randomized high-risk (T3,4 and/or node positive), completely resected gastric or gastroesophageal adenocarcinomas to receive either observation alone or radiochemotherapy after complete resection. Radiochemotherapy produced significant improvements in relapse-free (p < 0.0001) and overall survival (p = 0.01). Radiation oncologists must now clearly comprehend the principles governing the rationale supporting this therapy to apply it to those afflicted with this disease. This paper represents a consensus report reviewing data supporting radiotherapy, important clinical and anatomic issues related to radiotherapy, and details of the practical application of radiation therapy to commonly occurring clinical presentations. Supportive therapy during and after radiochemotherapy is also discussed. Copyright © 2002 Elsevier Science Inc. |
| Keywords: | treatment outcome; surgical technique; treatment failure; disease course; fluorouracil; treatment planning; chemotherapy, adjuvant; radiotherapy, adjuvant; cancer staging; recurrence risk; lymph node metastasis; lymphatic metastasis; metastasis; computer assisted tomography; neoplasm recurrence, local; radiation; radiotherapy; tomography, x-ray computed; calcium; practice guideline; oncology; high risk patient; survival time; tumors; randomized controlled trials; adjuvant chemotherapy; iron; serotonin antagonist; gastrectomy; stomach cancer; antiemetic agent; malnutrition; radiation induced emesis; stomach adenocarcinoma; anastomosis; stomach neoplasms; esophagus carcinoma; patterns of failure; ulcer; stomach; radiation treatment planning; cyanocobalamin; gastric cancer; supportive care; acid; histamine h2 receptor antagonist; phase iii trials; prochlorperazine maleate; postoperative nausea; humans; human; priority journal; article; nutrition physiology; gastric surgical adjuvant radiotherapy |
| Journal Title: | International Journal of Radiation Oncology, Biology, Physics |
| Volume: | 52 |
| Issue: | 2 |
| ISSN: | 0360-3016 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-02-01 |
| Start Page: | 283 |
| End Page: | 293 |
| Language: | English |
| DOI: | 10.1016/s0360-3016(01)02646-3 |
| PUBMED: | 11872272 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
