Postoperative adjuvante Chemoradiotherapie beim Hochrisikomagenkarzinom Journal Article
| Authors: | Shah, M. A.; Kelsen, D. P. |
| Article Title: | Postoperative adjuvante Chemoradiotherapie beim Hochrisikomagenkarzinom |
| Abstract: | Gastric cancer is a common cancer worldwide with a high mortality rate. Despite curative intent resection, locoregional failure as a frequent site of recurrence is responsible in part for this high mortality. Many attempts have been made to decrease the risk of recurrence after resection. Studies involving postoperative chemotherapy as a single modality have not clearly demonstrated benefit. Similarly, most studies of postoperative radiation therapy have not clearly shown an improvement in overall survival. Recently, however, a USA Intergroup study indicated a survival advantage for chemoradiation therapy compared to surgery alone for patients with locally advanced gastric cancer. "Intergroup-116" is a large-scale randomized trial designed to evaluate the role of adjuvant chemotherapy plus radiotherapy following curative intent gastric resection. The data from this study demonstrate a survival benefit with adjuvant chemoradiation that may in large part be due to better locoregional control. While many patients had a less then adequate lymph node dissection, survival was not associated with the type of lymph node dissection performed. Toxicity was acceptable. "Intergroup-116" indicates that postoperative chemoradiation should be considered as a standard care option for patients with locally advanced gastric cancer. Future studies should evaluate potentially more effective systemic therapy, molecularly-directed treatment, and possibly, whether or not more formal lymph node dissections would obviate the need for radiation. |
| Keywords: | survival rate; clinical trial; mortality; multimodality cancer therapy; adjuvant therapy; comparative study; chemotherapy, adjuvant; combined modality therapy; radiotherapy, adjuvant; cancer staging; neoplasm staging; lymph node excision; lymphadenectomy; controlled clinical trial; randomized controlled trial; pathology; risk; evaluation; randomized controlled trials; adjuvant chemotherapy; gastrectomy; stomach neoplasms; stomach tumor; humans; human; article |
| Journal Title: | Der Chirurg |
| Volume: | 73 |
| Issue: | 4 |
| ISSN: | 0009-4722 |
| Publisher: | Springer |
| Date Published: | 2002-04-01 |
| Start Page: | 325 |
| End Page: | 330 |
| Language: | German |
| PUBMED: | 12063916 |
| PROVIDER: | scopus |
| DOI: | 10.1007/s00104-002-0459-8 |
| DOI/URL: | |
| Notes: | Postoperative adjuvant chemoradiotherapy in high risk stomach carcinoma -- Export Date: 14 November 2014 -- Source: Scopus |
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