Prospective epidemiologic analysis of triazole-resistant nosocomial Candia glabrata isolated from patients at a comprehensive cancer center Journal Article
| Authors: | Safdar, A.; Armstrong, D.; Cross, E. W.; Perlin, D. S. |
| Article Title: | Prospective epidemiologic analysis of triazole-resistant nosocomial Candia glabrata isolated from patients at a comprehensive cancer center |
| Abstract: | Objective: The emergence of Candida glabrata infections among patients with compromised immunity has become a serious concern, especially at centers caring for individuals with cancer. Methods: During a prospective evaluation of Candida species associated with either clinically significant colonization or infection, 26.9% of C glabrata isolates showed in vitro resistance to fluconazole (MIC of ≥ 64 μg/ml). Results: Antifungal susceptibility profiles and genetic fingerprinting analysis performed by randomly amplified polymorphic DNA (RAPD) techniques confirmed low-probability of phenotypic and genotypic relatedness among nosocomial C. glabrata isolates. Conclusions: Presence of polyclonal strains of C. glabrata in patients at our hospital was probably related to selection of resistant yeasts from environmental pool rather than monoclonal expansion or clustering of multi-drug resistant C. glabrata in high-risk patients. |
| Keywords: | adult; clinical article; aged; aged, 80 and over; middle aged; genetics; pathogenesis; prospective study; prospective studies; neoplasm; neoplasms; classification; antifungal agent; drug effect; high risk patient; cancer center; antibiotic resistance; ketoconazole; hospital infection; microbiology; isolation and purification; microbiological examination; antibiotic sensitivity; fluconazole; candidiasis; antifungal agents; triazoles; cross infection; triazole derivative; itraconazole; minimum inhibitory concentration; fungus isolation; microbial sensitivity tests; drug resistance, fungal; candida glabrata; epidemiological data; amphotericin; humans; human; male; female; article; random amplified polymorphic dna; random amplified polymorphic dna technique |
| Journal Title: | International Journal of Infectious Diseases |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 1201-9712 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-09-01 |
| Start Page: | 198 |
| End Page: | 201 |
| Language: | English |
| DOI: | 10.1016/s1201-9712(02)90111-6 |
| PUBMED: | 12718835 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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