Solid-pseudopapillary tumor of the pancreas: A surgical enigma? Journal Article
| Authors: | Martin, R. C. G.; Klimstra, D. S.; Brennan, M. F.; Conlon, K. C. |
| Article Title: | Solid-pseudopapillary tumor of the pancreas: A surgical enigma? |
| Abstract: | Background: Solid-pseudopapillary tumors (SPTs) of the prancreas have been reported as rare lesions with "low malignant potential" occuring mainly in young women. This study was design to define the clinicopathological characteristics and the effect of the surgical intervention. Methods: A retrospective review from January 1985 to July 2000 was performed. Clinicopathologcal, operative, and survival data were obtained. The Kaplan-Meier method and X2 analysis were performed. All cases were re-reviewed by the a senior pathologist. Result: During this time, 24 patients were diagnosed as having SPTs (0.9%). Twenty females and four males were identified, with a median ages of 39 years (range, 12-79). the median size of t lesions was 8.0 cm (range, 1-20). Two patients' tumors were found to be unresectable at initial presentation because of vascular invasion; both patients have remained alive with disease, one for 13 years and the other 1 year. At a median follow-up of 8 years, one recurrence occured in 17 patients who underwent completed resection. Microcospic margin positive (P = .26), invasion of surrounding structures (P = .51), size >5 cm (P = .20) were not significant predictors of survival. Four patients presented with synchronous liver metastasis and underwent resection of the primary tumors and the liver metastasis, with one patients dying of progression of metastatic disease at 8 months, another alive with recurrecne in the liver at 6 years, and the last two alive without evidence of disease at 1 month and 11 years. Conclusions: SPT occurs predominantly in woman (82%), although it can occur in men; all age groups are affected. Complete resection is associated with long-term survival even in the presence of metastatic disease. |
| Keywords: | adolescent; adult; cancer survival; child; human tissue; aged; middle aged; survival analysis; retrospective studies; major clinical study; cancer recurrence; pancreatic neoplasms; lymphatic metastasis; incidence; carcinoma, papillary; liver metastasis; pancreas tumor; pseudotumor; papilloma; kaplan meier method; malignant transformation; tumor resection; solid-pseudopapillary tumor; humans; human; male; female; article; peripancreatic malignancy |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2002-01-01 |
| Start Page: | 35 |
| End Page: | 40 |
| Language: | English |
| DOI: | 10.1245/aso.2002.9.1.35 |
| PUBMED: | 11833495 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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