Adamantinomatous tumors: Long-term follow-up study of 20 patients treated at a single institution Journal Article
| Authors: | Schwarzkopf, E.; Tavarez, Y.; Healey, J. H.; Hameed, M.; Prince, D. E. |
| Article Title: | Adamantinomatous tumors: Long-term follow-up study of 20 patients treated at a single institution |
| Abstract: | Background and Objectives: Adamantinomas are primary, low-grade malignant tumors of the bone that have metastatic potential to the lungs, lymph nodes, and other regions. The rarity of this disease and its nonspecific symptoms complicate diagnosis. Materials and Methods: Records for 20 patients who underwent treatment for adamantinoma from 1975 to 2018 were reviewed for demographic, clinical, and pathological data, treatment details, postoperative complications, and outcomes. Results: Patients presented at a median age of 22 years (1-79 years): 14 patients had a localized primary tumor, three presented with local recurrence, and three with metastatic disease. Median tumor size was 5.7 cm (0.5-15.5 cm). Wide excision was performed primarily in 15 cases; the remaining five patients underwent intralesional curettage. At a median follow-up of 7.3 years, 14 patients had no evidence of disease; two patients were alive with disease, and four patients died from the disease. Local recurrence and distant metastasis occurred at a median of 11.4 years (6 month-19 years) and 15.8 years (4 month-23 years) after diagnosis. Conclusions: Adequate histopathological diagnosis is crucial to avoid misdiagnosis of this rare tumor. Local and distant recuAbs_Para_meprrence can occur more than 20 years after the initial diagnosis. Life-long follow-up with clinical examination and imaging is required. © 2020 Wiley Periodicals, Inc. |
| Keywords: | adolescent; adult; child; clinical article; human tissue; aged; middle aged; graft infection; primary tumor; clinical feature; histopathology; case report; cisplatin; sunitinib; diarrhea; drug withdrawal; side effect; systemic therapy; gemcitabine; nuclear magnetic resonance imaging; positron emission tomography; tumor volume; tinnitus; muscle flap; retrospective study; distant metastasis; docetaxel; irinotecan; postoperative complication; tumor recurrence; amputation; drug substitution; wound infection; soft tissue defect; functional status; tibia; curettage; bone radiography; fibula graft; low-grade; bone allograft; fracture nonunion; distraction osteogenesis; wide excision; clinical outcome; body weight loss; knee pain; pathologic fracture; bone-tumor; split thickness skin graft; ameloblastoma; bone swelling; human; male; female; priority journal; article; cortisone; osteofibrous dysplasia; x-ray computed tomography; adamantinoma; complex regional pain syndrome |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 122 |
| Issue: | 2 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2020-08-01 |
| Start Page: | 273 |
| End Page: | 282 |
| Language: | English |
| DOI: | 10.1002/jso.25950 |
| PUBMED: | 32334443 |
| PROVIDER: | scopus |
| PMCID: | PMC7547203 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 August 2020 -- Source: Scopus |
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