High expression of the Met receptor in prostate cancer metastasis to bone Journal Article
| Authors: | Knudsen, B. S.; Gmyrek, G. A.; Inra, J.; Scherr, D. S.; Vaughan, E D.; Nanus, D. M.; Kattan, M. W.; Gerald, W. L.; Vande Woude, G. F. |
| Article Title: | High expression of the Met receptor in prostate cancer metastasis to bone |
| Abstract: | Objectives. Expression of the active Met receptor tyrosine kinase causes tumor metastasis in animal models. To begin to analyze whether Met expression might be related to the spread of prostate cancer cells, we investigated whether its expression correlates with prostate-specific antigen recurrence and whether its expression depends on the site of metastasis. Methods. Ninety radical prostatectomy specimens with a Gleason sum of 6 or 7 and 86 specimens of bone, lymph node, and soft-tissue metastasis were immunohistochemically stained for Met, and a semiquantitative scoring system for Met in heterogeneously positive prostate cancers was applied. Met protein in prostate cancer cell lines was measured by Western blotting. Results. With the exception of two lymph node metastases, all metastases and 51% of the primary prostate cancers expressed Met. Moreover, the bone metastases expressed significantly more Met than did the lymph node metastases. However, in prostate cancer with a Gleason sum of 6 or 7, Met was not a prognostic marker for prostate-specific antigen recurrence. In prostate cancer cell lines, Met expression correlated inversely with expression of the androgen receptor. Conclusions. The high expression of the Met receptor tyrosine kinase in bone metastasis renders Met a promising target for nuclear imaging and treatment of metastatic prostate cancer. © 2002, Elsevier Science Inc. |
| Keywords: | immunohistochemistry; controlled study; human tissue; protein expression; bone neoplasms; major clinical study; cancer localization; cancer recurrence; bone metastasis; disease marker; lymph node metastasis; biological marker; prostate specific antigen; neoplasm proteins; cancer cell culture; protein tyrosine kinase; prostate-specific antigen; prostatic neoplasms; prostate; correlation analysis; prostatectomy; quantitative analysis; cancer cell; western blotting; scoring system; androgen receptor; protein determination; prostate carcinoma; scatter factor receptor; soft tissue metastasis; proto-oncogene proteins c-met; humans; prognosis; human; male; priority journal; article |
| Journal Title: | Urology |
| Volume: | 60 |
| Issue: | 6 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-12-01 |
| Start Page: | 1113 |
| End Page: | 1117 |
| Language: | English |
| DOI: | 10.1016/s0090-4295(02)01954-4 |
| PUBMED: | 12475693 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
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