Syndecan-1 expression in locally invasive and metastatic prostate cancer Journal Article
| Authors: | Chen, D.; Adenekan, B.; Chen, L.; Vaughan, E D.; Gerald, W.; Feng, Z. D.; Knudsen, B. S. |
| Article Title: | Syndecan-1 expression in locally invasive and metastatic prostate cancer |
| Abstract: | Objectives. To determine the significance of syndecan-1 expression, a cell-surface heparan sulfate proteoglycan in localized and metastatic prostate cancer. Methods. We performed a retrospective analysis of 76 men with Gleason sum 6 or 7 prostate cancer treated by radical prostatectomy and a separate cohort of 75 men with metastatic prostate cancer. Syndecan-1 immunoreactivity was measured in primary prostate specimens or in samples from metastatic sites and correlated with patient outcome. Results. Syndecan-1 was expressed in normal basal and secretory epithelial cells, 26% of radical prostatectomy specimens, and 35% of metastatic disease. No association was found between syndecan-1 positivity and prostate-specific antigen recurrence in the collective cohort of Gleason sum 6 and 7 cancers. However, when stratified by Gleason sum, syndecan-1 immunoreactivity (immunoreactivity score 150 or greater) was associated with a greater recurrence rate in Gleason sum 7 cancers. Expression of syndecan-1 was significantly greater in soft tissue than in bone metastasis (P = 0.048, Fisher's exact test). Conclusions. Consistent with a possible biochemical role for synclecan-1 in prostate cancer progression and metastasis, synclecan-1 expression correlated with serologic recurrence in Gleason sum 7 prostate cancer and was highly expressed in soft-tissue metstatases. (C) 2004 Elsevier Inc. |
| Keywords: | progression; carcinoma; radical prostatectomy; receptor; uterine cervix; myeloma; prognostic-significance; association; cell-adhesion; growth-factor-binding |
| Journal Title: | Urology |
| Volume: | 63 |
| Issue: | 2 |
| ISSN: | 0090-4295 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2004-02-01 |
| Start Page: | 402 |
| End Page: | 407 |
| Language: | English |
| ACCESSION: | WOS:000188995300047 |
| DOI: | 10.1016/j.urology.2003.08.036 |
| PROVIDER: | wos |
| PUBMED: | 14972511 |
| Notes: | Article -- Source: Wos |
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