Measuring health-related quality of life in patients with hepatobiliary cancers: The functional assessment of Cancer Therapy-Hepatobiliary Questionnaire Journal Article


Authors: Heffernan, N.; Cella, D.; Webster, K.; Odom, L.; Martone, M.; Passik, S.; Bookbinder, M.; Fong, Y.; Jarnagin, W.; Blumgart, L.
Article Title: Measuring health-related quality of life in patients with hepatobiliary cancers: The functional assessment of Cancer Therapy-Hepatobiliary Questionnaire
Abstract: Purpose: This is the first report on the development and initial validation of the Functional Assessment of Cancer Therapy-Hepatobiliary (FACT-Hep) questionnaire, a 45-item self-report instrument designed to measure health-related quality of life (HRQL) in patients with hepatobiliary cancers. The FACT-Hep consists of the 27-item FACT-G, which assesses generic HRQL concerns, and the newly validated 18-item Hepatobiliary Subscale (HS), which assesses disease-specific issues. Patients and Methods: The development of the HS followed a four-phase process of item generation, item reduction, scale construction, and reliability/validity testing. Two independent samples were studied: item generation (sample 1; n = 30) and reliability/validity testing (sample 2; n = 51). Results: In sample 2, all subscales and aggregated scores showed high internal consistency at initial assessment (Cronbach's alpha range, 0.72 to 0.94) and retesting (Cronbach's alpha range, 0.81 to 0.94). Measurement stability over a 3- to 7-day period was also high for all aggregated scales (test-retest correlation range, 0.84 to 0.91; intraclass correlation coefficient range, 0.82 to 0.90). Convergent and divergent validity were demonstrated by examining relationships between FACT subscales and mood, social support, and social desirability. Finally, when performance status and treatment status were used to divide sample 2, the HS differentiated groups to a degree comparable to the Physical and Functional Well-Being subscales of the FACT-G, thereby contributing favorably to a 32-item Trial Outcome Index. In addition to the 18 validated, scored items in the HS, seven treatment-related items may be appended, if clinically indicated, as a separate subscale. Conclusion: The 45-item FACT-Hep can be used independently as a brief measure of disease-related symptoms and functioning. Alone or paired with the FACT-G, the HS has promise for use in assessing the disease-specific HRQL of patients with hepatobiliary cancers. © 2002 by American Society of Clinical Oncology.
Keywords: adult; treatment outcome; aged; aged, 80 and over; middle aged; major clinical study; fatigue; liver neoplasms; cancer patient; reproducibility of results; quality of life; oncology; questionnaires; questionnaire; depression; rating scale; biliary tract neoplasms; self assessment (psychology); psychometrics; hepatobiliary system cancer; humans; human; male; female; priority journal; article
Journal Title: Journal of Clinical Oncology
Volume: 20
Issue: 9
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2002-05-01
Start Page: 2229
End Page: 2239
Language: English
DOI: 10.1200/jco.2002.07.093
PUBMED: 11980994
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Steven D Passik
    115 Passik
  2. Leslie H Blumgart
    343 Blumgart
  3. William R Jarnagin
    596 Jarnagin
  4. Yuman Fong
    745 Fong