Measuring health-related quality of life in leukemia: The functional assessment of cancer therapy - Leukemia (FACT-Leu) questionnaire Journal Article


Authors: Cella, D.; Jensen, S. E.; Webster, K.; Hongyan, D.; Lai, J. S.; Rosen, S.; Tallman, M. S.; Yount, S.
Article Title: Measuring health-related quality of life in leukemia: The functional assessment of cancer therapy - Leukemia (FACT-Leu) questionnaire
Abstract: Objective: Develop and validate a health-related quality-of-life (measure for patients with acute and chronic leukemia. Methods: The study consisted of two phases: scale construction and scale validation. For the item-generation phase, a summary of the literature combined with qualitative results from item-generation interviews with 29 acute or chronic leukemia patients and 16 health care providers yielded an initial item pool reflecting leukemia-specific concerns and symptoms. Items underwent iterations of review and reduction according to defined retention criteria to support content validity, as defined by priority concerns of patients. Seventeen final leukemia-specific items were combined with the Functional Assessment of Cancer Therapy-General to create the FACT-Leukemia (FACT-Leu) scale. For the validation phase, 79 individuals with acute or chronic leukemia completed questionnaires at three time points. Results: All FACT-Leu subscale and aggregated scores showed high internal consistency (αs ranging from 0.75 to 0.96). Test-retest reliability was adequate for all subscales (intraclass correlation range 0.765-0.890). The FACT-Leu scale demonstrated good convergent validity, with significant correlations with quality-of-life criteria and performance status, in the expected direction. FACT-Leu subscale scores were significantly different among the three performance status change groups, suggesting good responsiveness to change. Conclusions: The FACT-Leu scale is a valid, reliable, and efficient measure of leukemia-specific health-related quality of life for acute and chronic disease. © 2012 International Society for Pharmacoeconomics and Outcomes Research (ISPOR). Published by Elsevier Inc.
Keywords: adult; controlled study; aged; aged, 80 and over; middle aged; leukemia; major clinical study; quality of life; validation study; questionnaires; chronic disease; questionnaire; acute leukemia; health care personnel; rating scale; interview; content validity; test retest reliability; health-related quality of life; patient-reported outcomes; validation studies as topic; acute disease; internal consistency; qualitative analysis; chronic leukemia; functional assessment of cancer therapy leukemia questionnaire
Journal Title: Value in Health
Volume: 15
Issue: 8
ISSN: 1098-3015
Publisher: Elsevier Science, Inc.  
Date Published: 2012-12-15
Start Page: 1051
End Page: 1058
Language: English
DOI: 10.1016/j.jval.2012.08.2210
PROVIDER: scopus
PUBMED: 23244807
DOI/URL:
Notes: --- - "Export Date: 2 January 2013" - "CODEN: VIHLF" - "Source: Scopus"
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  1. Martin Stuart Tallman
    504 Tallman