BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function Journal Article
| Authors: | Dyomin, V. G.; Chaganti, S.; Dyomina, K.; Palanisamy, N.; Murty, V. V. V. S.; Dalla-Favera, R.; Chaganti, R. S. K. |
| Article Title: | BCL8 is a novel, evolutionarily conserved human gene family encoding proteins with presumptive protein kinase A anchoring function |
| Abstract: | BCL8 is a novel human gene family initially identified through cloning of BCL8A, located at the t(14;15)(q32;q11-q13) translocation breakpoint, in a case of diffuse large B-cell lymphoma. Multiple copies of BCL8A map to the 1-Mb proximal duplicated region at 15q. We identified additional copies on human chromosomes 13 (BCL8B), 22 (BCL8C), 2 (BCL8D), and 10 (BCL8E) by cDNA cloning and sequence analysis. BCL8A, BCL8C, BCL8D, and BCL8E are truncated at the genomic level and are presumably pseudogenes or sterile transcripts. BCL8B is expressed predominantly in human brain and encodes a 327-kDa protein with extensive homology to the Drosophila melanogaster protein kinase A anchoring protein RG. LRBA, a human gene with a ubiquitous expression pattern mapping to 4q32, encodes a protein closely related to BCL8. The phylogenetically conserved BCL8 gene family evolved by transchromosomal and intrachromosomal duplications within the human genome. |
| Keywords: | controlled study; human tissue; unclassified drug; sequence analysis; nonhuman; mouse; animal tissue; in situ hybridization, fluorescence; gene expression; gene expression profiling; neoplasm proteins; protein; genetic transcription; animalia; evolution, molecular; molecular cloning; gene mapping; conserved sequence; brain; nucleotide sequence; carrier proteins; gene duplication; drosophila melanogaster; protein kinase a; gene dosage; sequence homology; chromosome 13; genetic conservation; complementary dna; multigene family; dna, complementary; sequence analysis, dna; phylogeny; cyclic amp dependent protein kinase; cyclic amp-dependent protein kinases; pseudogene; melanogaster; chromosome duplication; humans; human; male; priority journal; article; 15q proximal duplication; bcl8; interchromosomal duplication; intrachromosomal duplication; kinase anchoring protein; lrba; nbea; t(14; 15)(q32; q11-q13); protein bcl 8; protein lbra |
| Journal Title: | Genomics |
| Volume: | 80 |
| Issue: | 2 |
| ISSN: | 0888-7543 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2002-08-01 |
| Start Page: | 158 |
| End Page: | 165 |
| Language: | English |
| DOI: | 10.1006/geno.2002.6822 |
| PUBMED: | 12160729 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work