PROGINS Alu insertion and human genomic diversity Journal Article
| Authors: | Donaldson, C. J.; Crapanzano, J. P.; Watson, J. C.; Levine, E. A.; Batzer, M. A. |
| Article Title: | PROGINS Alu insertion and human genomic diversity |
| Abstract: | A polymorphic Alu element belonging to the young Ya5 subfamily of Alu repeats located in the progesterone receptor gene has been characterized. Using a polymerase chain reaction (PCR)-based assay, the genetic diversity associated with the PROGINS Alu repeat was determined in a diverse array of human populations. The level of insertion polymorphism associated with PROGINS suggests that it will be a useful marker for the study of human evolution. In addition, we determined the distribution of the PROGINS Alu insertion in two groups of women from greater New Orleans, LA with breast cancer. The PROGINS Alu insertion was not associated with breast cancer in the populations tested. © 2002 Elsevier Science B.V. All rights reserved. |
| Keywords: | controlled study; nonhuman; united states; animal cell; animals; breast cancer; genetic variability; evolution; breast neoplasms; receptors, progesterone; progesterone receptor; gene insertion; receptor gene; genome, human; dna polymorphism; phylogeny; variation (genetics); louisiana; alu sequence; alu elements; humans; human; female; priority journal; article; insertion sequences; identical by descent; mobile element |
| Journal Title: | Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis |
| Volume: | 501 |
| Issue: | 1-2 |
| ISSN: | 0027-5107 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2002-04-25 |
| Start Page: | 137 |
| End Page: | 141 |
| Language: | English |
| DOI: | 10.1016/s0027-5107(02)00015-5 |
| PUBMED: | 11934445 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
