Mutational analyses of connexin 26, connexin 30 and connexin 46 as candidate tumor suppressor genes in parathyroid carcinoma Journal Article

  


Authors: Costa, J.; Shattuck, T. M.; Imanishi, Y.; Palanisamy, N.; Gaz, R. D.; Shoback, D.; Clark, O. H.; Monchik, J. M.; Wierman, M. E.; Hollenberg, A.; Tojo, K.; Chaganti, R. S. K.; Arnold, A.
Article Title: Mutational analyses of connexin 26, connexin 30 and connexin 46 as candidate tumor suppressor genes in parathyroid carcinoma
Abstract: Acquired loss of heterozygosity or deletion on 13q is frequently detected in parathyroid carcinoma, suggesting the presence of a parathyroid tumor suppressor gene in this location. Connexins make up the functional unit of gap junctional intercellular communication (GJIC), forming channels allowing passage of small molecules and ions between adjacent cells. Defects in GJIC have been observed in tumor cells and decreased cyclin D1 expression has resulted from forced connexin expression in cancer cells. Given the evidence suggesting 13q-based connexins as important candidate parathyroid tumor suppressors, we tested this hypothesis by examining the coding regions of connexin 26, connexin 30 and connexin 46 for somatic mutations in 13 parathyroid carcinomas. No mutations, insertions, or microdeletions were detected. Based on the absence of identifiable inactivating mutations, it is highly unlikely that connexin 26, connexin 30 or connexin 46 commonly function as classical tumor suppressor genes in the pathogenesis of parathyroid carcinoma.
Keywords: controlled study; human tissue; protein expression; unclassified drug; gene mutation; somatic mutation; pathogenesis; polymerase chain reaction; hypercalcemia; mutational analysis; tumor suppressor gene; dna; hyperparathyroidism; cyclin d1; cell communication; chromosomes; gap junction protein; parathyroid carcinoma; chromosome 13q; gap junction; connexin 26; human; article; neoplasm/* genetics; pair 13; connexin 30; connexin 46
Journal Title: Journal of Endocrine Genetics
Volume: 3
Issue: 2
ISSN: 1565-012X
Publisher: Freund Publishing Houe  
Date Published: 2002-04-01
Start Page: 57
End Page: 62
Language: English
PROVIDER: scopus
DOI: 10.1515/ijdhd.2002.3.2.57
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0036957368&partnerID=40&md5=d64c99be8f24e0e12120b46e504bd139
Notes: Export Date: 14 November 2014 -- Source: Scopus
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MSK Authors
  1. Nallasivam Palanisamy
    29 Palanisamy
  2. Raju S K Chaganti
    391 Chaganti
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