Granulomatous Pneumocystis carinii pneumonia in patients with malignancy Journal Article
| Authors: | Bondoc, A. Y. P.; White, D. A. |
| Article Title: | Granulomatous Pneumocystis carinii pneumonia in patients with malignancy |
| Abstract: | Background: A review was undertaken of the clinical features and results of diagnostic tests in non-HIV infected patients who developed granulomatous Pneumocystis carinii pneumonia (PCP). Methods: A retrospective review was performed of the charts and radiographs of patients with a granulomatous reaction to P carinii identified from computerised pathology records at Memorial Sloan Kettering Cancer Center, a university affiliated tertiary care hospital. Results: Three cases were identified; the incidence of granulomatous PCP was 3%. All patients had risk factors for PCP and had received high dose corticosteroids which had been stopped. Two patients had received chemotherapy. Presentation was insidious with only mild symptoms; only one patient had fever. Chest radiographs showed a reticulonodular pattern. Bronchoscopy was negative for PCP in all cases and open lung biopsy was necessary. Conclusion: A granulomatous pathological reaction to PCP occurs rarely in patients with malignancy. In these cases the clinical presentation may be atypical and bronchoscopy can be non-diagnostic. |
| Keywords: | adolescent; adult; human tissue; treatment outcome; middle aged; antibiotic agent; retrospective studies; fludarabine; prednisone; case report; doxorubicin; cancer combination chemotherapy; cancer patient; antineoplastic agent; cyclophosphamide; pneumocystis pneumonia; chlormethine; procarbazine; thiotepa; vinblastine; hodgkin disease; vincristine sulfate; glioblastoma; bleomycin; bronchoscopy; lactate dehydrogenase; corticosteroid; chronic lymphatic leukemia; cotrimoxazole; pentamidine; granuloma; anti-infective agents; lung granuloma; bronchoalveolar lavage fluid; pneumocystis infections; trimethoprim-sulfamethoxazole combination; pneumocystis carinii; humans; human; male; female; priority journal; article; open lung biopsy |
| Journal Title: | Thorax |
| Volume: | 57 |
| Issue: | 5 |
| ISSN: | 0040-6376 |
| Publisher: | BMJ Publishing Group Ltd. |
| Date Published: | 2002-05-01 |
| Start Page: | 435 |
| End Page: | 437 |
| Language: | English |
| DOI: | 10.1136/thorax.57.5.435 |
| PUBMED: | 11978921 |
| PROVIDER: | scopus |
| PMCID: | PMC1746334 |
| DOI/URL: | |
| Notes: | Export Date: 14 November 2014 -- Source: Scopus |
