Granulomatous Pneumocystis carinii pneumonia in patients with malignancy Journal Article

Authors: Bondoc, A. Y. P.; White, D. A.
Article Title: Granulomatous Pneumocystis carinii pneumonia in patients with malignancy
Abstract: Background: A review was undertaken of the clinical features and results of diagnostic tests in non-HIV infected patients who developed granulomatous Pneumocystis carinii pneumonia (PCP). Methods: A retrospective review was performed of the charts and radiographs of patients with a granulomatous reaction to P carinii identified from computerised pathology records at Memorial Sloan Kettering Cancer Center, a university affiliated tertiary care hospital. Results: Three cases were identified; the incidence of granulomatous PCP was 3%. All patients had risk factors for PCP and had received high dose corticosteroids which had been stopped. Two patients had received chemotherapy. Presentation was insidious with only mild symptoms; only one patient had fever. Chest radiographs showed a reticulonodular pattern. Bronchoscopy was negative for PCP in all cases and open lung biopsy was necessary. Conclusion: A granulomatous pathological reaction to PCP occurs rarely in patients with malignancy. In these cases the clinical presentation may be atypical and bronchoscopy can be non-diagnostic.
Keywords: adolescent; adult; human tissue; treatment outcome; middle aged; antibiotic agent; retrospective studies; fludarabine; prednisone; case report; doxorubicin; cancer combination chemotherapy; cancer patient; antineoplastic agent; cyclophosphamide; pneumocystis pneumonia; chlormethine; procarbazine; thiotepa; vinblastine; hodgkin disease; vincristine sulfate; glioblastoma; bleomycin; bronchoscopy; lactate dehydrogenase; corticosteroid; chronic lymphatic leukemia; cotrimoxazole; pentamidine; granuloma; anti-infective agents; lung granuloma; bronchoalveolar lavage fluid; pneumocystis infections; trimethoprim-sulfamethoxazole combination; pneumocystis carinii; humans; human; male; female; priority journal; article; open lung biopsy
Journal Title: Thorax
Volume: 57
Issue: 5
ISSN: 0040-6376
Publisher: BMJ Publishing Group Ltd.  
Date Published: 2002-05-01
Start Page: 435
End Page: 437
Language: English
DOI: 10.1136/thorax.57.5.435
PUBMED: 11978921
PROVIDER: scopus
PMCID: PMC1746334
Notes: Export Date: 14 November 2014 -- Source: Scopus
Citation Impact
MSK Authors
  1. Dorothy A White
    73 White