Stanford V program for locally extensive and advanced Hodgkin lymphoma: The Memorial Sloan-Kettering Cancer Center experience Journal Article
| Authors: | Edwards-Bennett, S. M.; Jacks, L. M.; Moskowitz, C. H.; Wu, E. J.; Zhang, Z.; Noy, A.; Portlock, C. S.; Straus, D. J.; Zelenetz, A. D.; Yahalom, J. |
| Article Title: | Stanford V program for locally extensive and advanced Hodgkin lymphoma: The Memorial Sloan-Kettering Cancer Center experience |
| Abstract: | Background: The Stanford group has reported excellent results with the Stanford V regimen for patients with bulky and/or advanced Hodgkin lymphoma (HL). However, Gobbi reported markedly inferior failure-free survival (FFS) comparing Stanford V to other regimens but included major deviations from the original program. We retrospectively examined whether treatment at our institution carefully following Stanford V guidelines would confirm the original Stanford outcome data. Patients and methods: From June 1995 to May 2002, 126 patients with either locally extensive or advanced HL were treated with the 12-week Stanford V chemotherapy program followed by 36-Gy involved-field radiotherapy to sites initially 5 cm and/or to macroscopic splenic disease. Overall, 26% had stage IV disease and 20% had international prognostic score (IPS)>= 4. Overall survival (OS), disease-specific survival, progression-free survival (PFS), FFS, and freedom from second relapse (FF2R) were determined. Results: The 5- and 7-year OS were 90% and 88%, respectively. The 5-year FFS was 78%. IPS 4 was a significant independent predictor of worse OS and PFS. The FF2R was 64% at 3 years. Conclusion: Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL. |
| Keywords: | chemotherapy; standard; hodgkin lymphoma; trial; disease; combined modality; involved-field radiotherapy; stanford v; abvd; hazards; mopp |
| Journal Title: | Annals of Oncology |
| Volume: | 21 |
| Issue: | 3 |
| ISSN: | 0923-7534 |
| Publisher: | Oxford University Press |
| Date Published: | 2010-03-01 |
| Start Page: | 574 |
| End Page: | 581 |
| Language: | English |
| ACCESSION: | ISI:000276045300022 |
| DOI: | 10.1093/annonc/mdp337 |
| PROVIDER: | wos |
| PUBMED: | 19759185 |
| Notes: | --- - Article - "Source: Wos" |
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