Association of the time of day of chemoradiotherapy and durvalumab with tumor control in lung cancer Journal Article
| Authors: | McMillan, M. T.; Shepherd, A.; Cooper, A. J.; Schoenfeld, A. J.; Wu, A. J.; Simone, C. B. 2nd; Iyengar, P.; Gelblum, D. Y.; Chaft, J. E.; Gomez, D. R.; Shaverdian, N. |
| Article Title: | Association of the time of day of chemoradiotherapy and durvalumab with tumor control in lung cancer |
| Abstract: | Background/purpose: The circadian clock governs the expression of genes related to immunity and DNA repair. We investigated whether the time of day of radiotherapy and/or systemic therapy infusions (chemotherapy or anti-PD-L1) are associated with disease control and survival in locally advanced non-small cell lung cancer (LA-NSCLC). Materials/methods: 178 consecutive patients with inoperable LA-NSCLC who received definitive chemoradiotherapy followed by durvalumab between 5/2017–8/2022 were reviewed. Outcomes evaluated included progression-free survival (PFS), distant metastasis-free survival (DMFS), locoregional control (LRC), and overall survival (OS). Results: At a median follow up of 48.0 mo from durvalumab initiation, median PFS and OS were 26.2 mo and 50.0 mo, respectively. Median LRC and DMFS were not reached and 41.0 mo, respectively. Receiving > 50 % (N = 23) versus ≤ 50 % (N = 155) of radiotherapy treatments within 3 h of sunset was associated with younger age; otherwise, there were no other differences between cohorts. There were no significant differences in characteristics between patients who received > 50 % (N = 23) versus ≤ 50 % (N = 155) of durvalumab infusions within 3 h of sunset. On multivariable analysis, receiving > 50 % of radiotherapy treatments within 3 h of sunset was independently associated with reduced risk for progression (HR 0.39, p = 0.017) and distant metastasis (HR 0.27, p = 0.007); conversely, receiving > 50 % of durvalumab infusions within 3 h of sunset was independently associated with increased risk for distant metastasis (HR 2.13, p = 0.025). The timing of chemotherapy was not associated with disease outcomes. Conclusion: The time of day of radiotherapy and durvalumab infusion may be associated with disease control in LA-NSCLC, and the optimal time of treatment depends on the treatment modality. © 2024 Elsevier B.V. |
| Keywords: | adult; cancer survival; controlled study; aged; major clinical study; overall survival; advanced cancer; progression free survival; radiotherapy; cohort analysis; lung cancer; distant metastasis; cancer control; risk reduction; non-small cell lung cancer; chemoradiotherapy; non small cell lung cancer; clinical outcome; circadian clock; distant metastasis free survival; human; male; female; article; chronotherapy; median survival time; durvalumab |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 203 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2025-02-01 |
| Start Page: | 110658 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2024.110658 |
| PUBMED: | 39626792 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors is MSK author: Narek Shaverdian -- Source: Scopus |
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