Unraveling the molecular genetics of head and neck cancer through genome-wide approaches Journal Article
| Authors: | Riaz, N.; Morris, L. G.; Lee, W.; Chan, T. A. |
| Article Title: | Unraveling the molecular genetics of head and neck cancer through genome-wide approaches |
| Abstract: | The past decade has seen an unprecedented increase in our understanding of the biology and etiology of head and neck squamous cell carcinomas (HNSCC). Genome-wide sequencing projects have identified a number of recurrently mutated genes, including unexpected alterations in the NOTCH pathway and chromatin related genes. Gene-expression profiling has identified 4 distinct genetic subtypes which show some parallels to lung squamous cell carcinoma biology. The identification of the human papilloma virus as one causative agent in a subset of oropharyngeal cancers and their association with a favorable prognosis has opened up avenues for new therapeutic strategies. The expanding knowledge of the underlying molecular abnormalities in this once very poorly understood cancer should allow for increasingly rational clinical trial design and improved patient outcomes. |
| Keywords: | protein kinase b; gene mutation; mutation; review; molecular genetics; lymph node metastasis; cancer susceptibility; disease association; gene expression; gene expression profiling; epidermal growth factor receptor; genetic association; notch receptor; mutational analysis; phosphatidylinositol 3 kinase; protein p53; cancer genetics; oncogene; tumor suppressor gene; head and neck cancer; chromatin; mammalian target of rapamycin; genomics; oropharynx cancer; chromosomal instability; caspase 8; protein p63; oxidative stress; lung squamous cell carcinoma; cyclin dependent kinase inhibitor 2a; cyclin d1; genetic predisposition; notch1 receptor; wart virus; copy number variation; e1a associated p300 protein; copy number; transcription factor nrf2; cancer prognosis; kelch like ech associated protein 1; human |
| Journal Title: | Genes & Diseases |
| Volume: | 1 |
| Issue: | 1 |
| ISSN: | 2352-3042 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-09-01 |
| Start Page: | 75 |
| End Page: | 86 |
| Language: | English |
| DOI: | 10.1016/j.gendis.2014.07.002 |
| PROVIDER: | scopus |
| PMCID: | PMC4310010 |
| PUBMED: | 25642447 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
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