Pancreatic neuroendocrine tumors: Pathologic and molecular characteristics Journal Article
| Authors: | Shi, C.; Klimstra, D. S. |
| Article Title: | Pancreatic neuroendocrine tumors: Pathologic and molecular characteristics |
| Abstract: | Pancreatic neuroendocrine neoplasms include mainly well-differentiated neuroendocrine tumors but also rare poorly differentiated neuroendocrine carcinomas. Molecular mechanisms underlying pancreatic neuroendocrine tumorigenesis have recently been elucidated. While alterations in the chromatin remodeling and PI3K/Akt/mTOR pathways are present in most well-differentiated pancreatic neuroendocrine tumors, mutations in TP53 and RB may contribute to the development of pancreatic poorly differentiated neuroendocrine carcinomas. With these discoveries, new molecular targeted therapies have become available and show promise in some patients with pancreatic well-differentiated neuroendocrine tumor. |
| Keywords: | immunohistochemistry; signal transduction; cancer chemotherapy; cancer surgery; genetics; clinical feature; pathophysiology; capecitabine; temozolomide; molecular genetics; pancreas; gene; neurofibromatosis; disease association; tumor differentiation; pathology; phosphatidylinositol 3 kinase; protein p53; pathological anatomy; tumors; mammalian target of rapamycin; methylated dna protein cysteine methyltransferase; genetic disorder; von hippel lindau disease; retinoblastoma protein; tuberous sclerosis; somatostatin derivative; chromatin assembly and disassembly; insulinoma; cyst; neuroendocrine; molecular pathology; molecularly targeted therapy; pancreatic neuroendocrine tumor; multiple endocrine neoplasia; tp53 gene; exome; human; article; men1 gene; rb gene |
| Journal Title: | Seminars in Diagnostic Pathology |
| Volume: | 31 |
| Issue: | 6 |
| ISSN: | 0740-2570 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-11-01 |
| Start Page: | 498 |
| End Page: | 511 |
| Language: | English |
| DOI: | 10.1053/j.semdp.2014.08.008 |
| PROVIDER: | scopus |
| PUBMED: | 25441311 |
| DOI/URL: | |
| Notes: | Export Date: 2 January 2015 -- Source: Scopus |
