Pericellular proteolysis in cancer Journal Article
| Authors: | Sevenich, L.; Joyce, J. A. |
| Article Title: | Pericellular proteolysis in cancer |
| Abstract: | Pericellular proteases have long been associated with cancer invasion and metastasis due to their ability to degrade extracellular matrix components. Recent studies demonstrate that proteases also modulate tumor progression and metastasis through highly regulated and complex processes involving cleavage, processing, or shedding of cell adhesion molecules, growth factors, cytokines, and kinases. In this review, we address how cancer cells, together with their surrounding microenvironment, regulate pericellular proteolysis. We dissect the multitude of mechanisms by which pericellular proteases contribute to cancer progression and discuss how this knowledge can be integrated into therapeutic opportunities. |
| Keywords: | metastasis; microenvironment; tumor; macrophages; invasion; migration; nf-kappa-b; proteases; cathepsin-b; tumor-associated macrophages; urokinase plasminogen-activator; metalloproteinase inducer emmprin; type-1 matrix-metalloproteinase; heparin-like glycosaminoglycans; growth-factor bioavailability; colorectal-carcinoma cells; soluble e-cadherin |
| Journal Title: | Genes and Development |
| Volume: | 28 |
| Issue: | 21 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2014-11-01 |
| Start Page: | 2331 |
| End Page: | 2347 |
| Language: | English |
| ACCESSION: | WOS:000344446300001 |
| DOI: | 10.1101/gad.250647.114 |
| PROVIDER: | wos |
| PMCID: | PMC4215179 |
| PUBMED: | 25367033 |
| Notes: | Review -- Source: Wos |
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