A novel Pseudomonas aeruginosa strain with an oprD mutation in relation to a nosocomial respiratory infection outbreak in an intensive care unit Journal Article
| Authors: | Yan, Y.; Yao, X.; Li, H.; Zhou, Z.; Huang, W.; Stratton, C. W.; Lu, C. D.; Tang, Y. W. |
| Article Title: | A novel Pseudomonas aeruginosa strain with an oprD mutation in relation to a nosocomial respiratory infection outbreak in an intensive care unit |
| Abstract: | Seven imipenem-resistant Pseudomonas aeruginosa isolates were recovered from the sputum samples of pneumonia patients in southwestern China. They had identical antibiotic resistance patterns and indistinguishable pulsed-field gel electrophoresis profiles. Nucleotide sequence analysis revealed a 4-bp (AGTC) insertion in the oprD gene, resulting in a frameshift in the cognate open reading frame. These isolates became imipenem susceptible when the chromosomal oprD lesion was complemented, indicating that the 4-bp insertion in the oprD gene resulted in imipenem resistance. |
| Journal Title: | Journal of Clinical Microbiology |
| Volume: | 52 |
| Issue: | 12 |
| ISSN: | 0095-1137 |
| Publisher: | American Society for Microbiology |
| Date Published: | 2014-12-01 |
| Start Page: | 4388 |
| End Page: | 4390 |
| Language: | English |
| DOI: | 10.1128/jcm.02782-14 |
| PROVIDER: | scopus |
| PUBMED: | 25297323 |
| PMCID: | PMC4313324 |
| DOI/URL: | |
| Notes: | Export Date: 1 December 2014 -- Source: Scopus |
